Egashira Koichi, Sueta Daisuke, Tomiguchi Mai, Kidoh Masafumi, Oda Seitaro, Usuku Hiroki, Hidaka Kaori, Goto-Yamaguchi Lisa, Sueta Aiko, Komorita Takashi, Takae Masafumi, Oike Fumi, Fujisue Koichiro, Yamamoto Eiichiro, Hanatani Shinsuke, Takashio Seiji, Arima Yuichiro, Araki Satoshi, Kaikita Koichi, Matsushita Kenichi, Yamamoto Yutaka, Hirai Toshinori, Tsujita Kenichi
Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto, Japan.
Center for Metabolic Regulation of Healthy Aging, Graduate School of Medical Sciences, Kumamoto, Japan.
Int J Cardiol Heart Vasc. 2021 May 18;34:100797. doi: 10.1016/j.ijcha.2021.100797. eCollection 2021 Jun.
Cardiotoxicity in the late phase after anthracycline drugs administration remains to be defined. Of the 44 patients who received anthracycline treatment, 7 were found to have cancer therapeutics-related cardiac dysfunction (CTRCD). The global longitudinal strain determined by echocardiography and myocardial extracellular volume fraction (ECV) determined by cardiac computed tomography (CCT) of the CTRCD(+) group were significantly higher than those of the control group and CTRCD(-) group, whereas there were no significant differences between the control and CTRCD(-) groups. Our findings indicated that CCT may be a tool comparable to echocardiography, indicating the effective evaluation of CTRCD by CCT.
蒽环类药物给药后期的心脏毒性仍有待明确。在接受蒽环类治疗的44例患者中，有7例被发现患有癌症治疗相关的心脏功能障碍（CTRCD）。CTRCD（+）组经超声心动图测定的整体纵向应变以及经心脏计算机断层扫描（CCT）测定的心肌细胞外容积分数（ECV）显著高于对照组和CTRCD（-）组，而对照组和CTRCD（-）组之间无显著差异。我们的研究结果表明，CCT可能是一种与超声心动图相当的工具，表明CCT可有效评估CTRCD。
