Yesilada E, Tanaka S, Sezik E, Tabata M
Faculty of Pharmaceutical Sciences, Kyoto University, Japan.
J Nat Prod. 1988 May-Jun;51(3):504-8. doi: 10.1021/np50057a008.
The fruit juice of Ecballium elaterium, used as a folk medicine in Turkey for the treatment of sinusitis, was investigated for its anti-inflammatory activity in mice. Fractions obtained from the juice were tested in mice for their effects on increased vascular permeability, as induced by HOAc ip. The active principle was isolated from the CHCl3 extract as well as the H2O-insoluble part of the fruit juice and identified as cucurbitacin B. This is the first report that cucurbitacin B has a significant anti-inflammatory activity.
药用夏南瓜的果汁在土耳其作为治疗鼻窦炎的民间药物使用，对其在小鼠体内的抗炎活性进行了研究。从果汁中获得的馏分在小鼠身上测试了其对乙酸腹腔注射诱导的血管通透性增加的影响。活性成分从果汁的氯仿提取物以及水不溶性部分中分离出来，鉴定为葫芦素B。这是关于葫芦素B具有显著抗炎活性的首次报道。
