精神分裂症患者左右侧运动神经元兴奋性的特定失衡。
Specific imbalance of right and left sided motor neuron excitability in schizophrenia.
作者信息
Goode D J, Manning A A
机构信息
Department of Psychiatry, Bowman Gray School of Medicine, Wake Forest University, Winston-Salem, NC 27103.
出版信息
J Neurol Neurosurg Psychiatry. 1988 May;51(5):626-9. doi: 10.1136/jnnp.51.5.626.
Abstract
Fifty-three psychiatric patients, 16 with schizophrenia, 19 with affective disorder, and 19 with schizo-affective disorder were diagnosed by Research Diagnostic Criteria. Hoffmann reflex recovery curves were measured in the right and left legs of each patient. In both affective disorder and schizo-affective disorder, recovery curve height in the right and left legs was highly correlated. In schizophrenia, recovery curve height in the right and left legs was not correlated. These results demonstrate a right-left asymmetry in motor neuron excitability specific to schizophrenia. The findings are compatible with a deficit in hemispheric transfer that is unique to schizophrenia. Other interpretations can be made, including diffuse cortical or subcortical dysfunction in schizophrenia which disrupts transfer or interpretation or intrahemispheric communication.
摘要
53名精神科患者，其中16名精神分裂症患者、19名情感障碍患者和19名精神分裂情感障碍患者，均按照研究诊断标准进行诊断。测量了每位患者左右腿的霍夫曼反射恢复曲线。在情感障碍和精神分裂情感障碍中，左右腿的恢复曲线高度高度相关。在精神分裂症中，左右腿的恢复曲线高度不相关。这些结果表明精神分裂症特有的运动神经元兴奋性存在左右不对称性。这些发现与精神分裂症特有的半球传递缺陷相符。也可以有其他解释，包括精神分裂症中弥漫性皮质或皮质下功能障碍，这会破坏传递或解释或半球内通信。
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本文引用的文献
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