Nasrallah H A, McCalley-Whitters M, Bigelow L B, Rauscher F P
Psychiatry Res. 1983 Apr;8(4):251-60. doi: 10.1016/0165-1781(83)90013-6.
As a followup to a post-mortem study of the brains of schizophrenic and control subjects where the corpus callosum was found to be significantly thicker anteriorly in early onset compared to late onset schizophrenia, histological sections of 18 schizophrenic, 7 manic-depressive, and 11 medical/surgical control subjects were prepared using a stain for glia and a stain for callosal fibers. A quantitative study of the concentration of glial cells and interhemispheric callosal fibers revealed no difference between groups. A neuropathologist unaware of the tissue origin rated the histological sections for gliosis. There was significantly more severe gliosis in the callosi of the late onset schizophrenics compared to early onset schizophrenics as well as the control group. These preliminary findings suggesting callosal pathology are discussed, and the need for further studies is stressed.
作为一项对精神分裂症患者和对照受试者大脑进行尸检研究的后续研究，研究发现早发性精神分裂症患者胼胝体前部比晚发性精神分裂症患者显著更厚。我们使用了一种针对神经胶质的染色剂和一种针对胼胝体纤维的染色剂，为18名精神分裂症患者、7名躁郁症患者和11名内科/外科对照受试者制备了组织学切片。对神经胶质细胞浓度和半球间胼胝体纤维的定量研究显示，各组之间没有差异。一名不知道组织来源的神经病理学家对组织学切片的神经胶质增生进行了评级。与早发性精神分裂症患者以及对照组相比，晚发性精神分裂症患者胼胝体中的神经胶质增生明显更严重。我们讨论了这些提示胼胝体病变的初步发现，并强调了进一步研究的必要性。
