Rugg M D, Cowan C P, Nagy M E, Milner A D, Jacobson I, Brooks D N
MRC Cognitive Neuroscience Research Group, University of St Andrews, Fife, UK.
J Neurol Neurosurg Psychiatry. 1988 May;51(5):691-8. doi: 10.1136/jnnp.51.5.691.
Event-related potentials (ERPs) were recorded from 19 closed head injury (CHI) patients, at least 6 months after injury, and an equal number of control subjects, during a task requiring the covert counting of rare auditory "target" stimuli against a background of frequent "non-targets". In both groups, ERPs to targets contained enhanced frontal N2 and parietal P3 components. N2 was larger in amplitude in the CHI patients than in the controls, and its peak latency was delayed. P3 amplitude was smaller in the patients, but its latency was not significantly different from that of the control group. The delay in N2 latency is interpreted as evidence of an increase in the time needed to achieve stimulus categorisation in CHI patients. The larger N2s in this group are thought to reflect the additional cognitive effort required after CHI to cope with the task. The negative findings with respect to P3 latency suggest that this may be a less sensitive measure of information-processing efficiency in this task than the latency of N2.
在一项任务中，对19名闭合性颅脑损伤（CHI）患者（受伤至少6个月后）和数量相同的对照受试者记录事件相关电位（ERP）。该任务要求在频繁出现的“非目标”背景中暗中计数罕见的听觉“目标”刺激。在两组中，对目标的ERP均包含增强的额叶N2和顶叶P3成分。CHI患者的N2波幅大于对照组，且其峰潜伏期延迟。患者的P3波幅较小，但其潜伏期与对照组无显著差异。N2潜伏期的延迟被解释为CHI患者实现刺激分类所需时间增加的证据。该组中较大的N2波被认为反映了CHI后应对任务所需的额外认知努力。关于P3潜伏期的阴性结果表明，在该任务中，这可能是一种比N2潜伏期对信息处理效率更不敏感的测量方法。
