MOE Key Laboratory for Analytical Science of Food Safety and Biology, College of Chemistry, Fuzhou University, Fujian Science & Technology Innovation Laboratory for Optoelectronic Information of China, Fuzhou, 350108, P. R. China.
State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, P. R. China.
Angew Chem Int Ed Engl. 2021 Aug 2;60(32):17647-17653. doi: 10.1002/anie.202105207. Epub 2021 Jun 29.
Controlling the structural order of nanoparticles (NPs), morphology, and composition is of paramount significance in tailoring the physical properties of nanoassembly. However, the commonly reported symmetrical nanocomposites often suffer an interference or sacrifice of the photophysical properties of the original components. To address this challenge, we developed a novel type of organic-inorganic Janus nanocomposite (JNCP) with an asymmetric architecture, offering unique features such as the precisely controlled localization of components, combined modular optical properties, and independent stimuli. As a proof of concept, JNCPs were prepared by incorporating two photoacoustic (PA) imaging agents, namely an organic semiconducting dye and responsive gold nanoparticles (AuNP) assembly in separate compartments of JNCP. Theoretical simulation results confirmed that the formation mechanism of JNCPs arises from the entropy equilibrium in the system. The AuNP assembly generated a PA images with the variation of pH, while the semiconducting molecule served as an internal PA standard agent, leading to ratiometric PA imaging of pH. JNCP based probe holds great potential for real-time and accurate detection of diverse biological targets in living systems.
控制纳米粒子（NPs）的结构有序性、形态和组成对于调整纳米组装体的物理性质至关重要。然而，常见的报道的对称纳米复合材料往往会干扰或牺牲原始组件的光物理性质。为了解决这一挑战，我们开发了一种具有不对称结构的新型有机-无机 Janus 纳米复合材料（JNCP），具有精确控制组件定位、组合模块光学性质和独立刺激等独特特点。作为概念验证，通过将两种光声（PA）成像剂，即有机半导体染料和响应性金纳米粒子（AuNP）组装在 JNCP 的单独隔室中，制备了 JNCP。理论模拟结果证实，JNCP 的形成机制源于系统中的熵平衡。AuNP 组装体在 pH 变化时产生 PA 图像，而半导体分子则作为内部 PA 标准剂，导致 pH 的比率 PA 成像。基于 JNCP 的探针在活体系统中对各种生物靶标进行实时、准确检测方面具有巨大潜力。
