Hawthorne Christopher, Quigley Niamh, McClements Callum, Lopez-Campos Guillermo H
Wellcome-Wolfson Institute for Experimental Medicine, Queen's University Belfast, Belfast, UK.
Stud Health Technol Inform. 2021 May 27;281:1079-1080. doi: 10.3233/SHTI210353.
Exposome research is focused on all the exposures individuals experience during their lifetime and how it shapes their health and development of disease. The chemical and biological aspects of the exposome are readily available in data formats. In comparison there is a lack of data frameworks available for physical factors (e.g. noise, lighting, electromagnetic fields) and their biological relationships which would allow a greater understanding of the contribution of the physical environment on disease development and burden. We present the construction of a prototype that captures knowledge on physical factors and their interactions with genes and diseases derived from the biomedical literature to reflect the physical exposome.
暴露组研究聚焦于个体一生中所经历的所有暴露因素，以及这些因素如何塑造他们的健康状况和疾病发展。暴露组的化学和生物学方面的数据格式很容易获取。相比之下，缺乏适用于物理因素（如噪音、光照、电磁场）及其生物学关系的数据框架，而这些框架有助于更深入地理解物理环境对疾病发展和负担的影响。我们展示了一个原型的构建，该原型获取了来自生物医学文献的关于物理因素及其与基因和疾病相互作用的知识，以反映物理暴露组。
