Via Department of Civil and Environmental Engineering, Virginia Polytechnic Institute and State University , Blacksburg Virginia 24061, United States.
Environ Sci Technol. 2017 Jul 18;51(14):7759-7774. doi: 10.1021/acs.est.7b01097. Epub 2017 Jul 5.
The "exposome" is a term describing the summation of one's lifetime exposure to microbes and chemicals. Such exposures are now recognized as major drivers of human health and disease. Because humans spend ∼90% of their time indoors, the built environment exposome merits particular attention. Herein we utilize an engineering perspective to advance understanding of the factors that shape the built environment exposome and its influence on human wellness and disease, while simultaneously informing development of a framework for intentionally controlling the exposome to protect public health. Historically, engineers have been focused on controlling chemical and physical contaminants and on eradicating microbes; however, there is a growing awareness of the role of "beneficial" microbes. Here we consider the potential to selectively control the materials and chemistry of the built environment to positively influence the microbial and chemical components of the indoor exposome. Finally, we discuss research gaps that must be addressed to enable intentional engineering design, including the need to define a "healthy" built environment exposome and how to control it.
“暴露组”是一个术语，用于描述一个人一生中接触微生物和化学物质的总和。这些暴露现在被认为是人类健康和疾病的主要驱动因素。由于人类 90%的时间都在室内度过，因此建筑环境暴露组尤其值得关注。在这里，我们利用工程学的视角来深入了解塑造建筑环境暴露组及其对人类健康和疾病影响的因素，同时为有针对性地控制暴露组以保护公众健康提供框架。从历史上看，工程师一直专注于控制化学和物理污染物以及消除微生物；然而，人们越来越意识到“有益”微生物的作用。在这里，我们考虑了选择性控制建筑环境的材料和化学物质的潜力，以积极影响室内暴露组的微生物和化学组成部分。最后，我们讨论了必须解决的研究空白，以实现有目的的工程设计，包括需要定义“健康”的建筑环境暴露组以及如何控制它。
