VIII 因子抗体结构与膜结合。
Factor VIII-antibody structure and membrane binding.
机构信息
VA Boston Healthcare System.
出版信息
Blood. 2021 May 27;137(21):2866-2868. doi: 10.1182/blood.2021010947.
Abstract
The cocrystal structure of antibody 2A9 and factor VIII (fVIII), reported by Gish et al in this issue of , delineates an epitope on the C1 domain and novel mobility of the C2 domain, both relevant to membrane binding.
摘要
Gish 等人在本期 杂志中报道了抗体 2A9 和因子 VIII（fVIII）的共晶结构，该结构描绘了 C1 结构域上的一个表位和 C2 结构域的新的运动性，这两者都与膜结合有关。
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本文引用的文献
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Uptake of blood coagulation factor VIII by dendritic cells is mediated via its C1 domain.树突状细胞通过其 C1 结构域摄取凝血因子 VIII。
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Membrane-binding properties of the Factor VIII C2 domain.因子 VIII C2 结构域的膜结合特性。
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