CIBORG Laboratory, Department of Radiology, Children's Hospital of Los Angeles, 4650 Sunset Blvd, Los Angeles, CA, 90027, USA.
Advanced Baby Imaging Lab, Hasbro Children's Hospital, 593 Eddy Street Ground Level, Providence, RI, 02903, USA.
Brain Struct Funct. 2021 Jul;226(6):1841-1853. doi: 10.1007/s00429-021-02292-x. Epub 2021 May 27.
The human brain grows rapidly in early childhood, reaching 95% of its final volume by age 6. Understanding brain growth in childhood is important both to answer neuroscience questions about anatomical changes in development, and as a comparison metric for neurological disorders. Metrics for neuroanatomical development including cortical measures pertaining to the sulci can be instrumental in early diagnosis, monitoring, and intervention for neurological diseases. In this paper, we examine the development of the central sulcus in children aged 12-60 months from structural magnetic resonance images. The central sulcus is one of the earliest sulci to develop at the fetal stage and is implicated in diseases such as Attention Deficit Hyperactive Disorder and Williams syndrome. We investigate the relationship between the changes in the depth of the central sulcus with respect to age. In our results, we observed a pattern of depth present early on, that had been previously observed in adults. Results also reveal the presence of a rightward depth asymmetry at 12 months of age at a location related to orofacial movements. That asymmetry disappears gradually, mostly between 12 and 24 months, and we suggest that it is related to the development of language skills.
人类大脑在幼儿期迅速发育，到 6 岁时达到最终体积的 95%。了解儿童期大脑发育对于回答关于发展中解剖结构变化的神经科学问题以及作为神经发育障碍的比较指标都很重要。神经解剖学发育的指标包括与脑沟有关的皮质测量值，对于神经疾病的早期诊断、监测和干预非常重要。在本文中，我们从结构磁共振图像中检查了 12-60 个月大的儿童中央沟的发育情况。中央沟是在胎儿期最早发育的脑沟之一，与注意力缺陷多动障碍和威廉姆斯综合征等疾病有关。我们研究了中央沟深度随年龄变化的关系。在我们的结果中，我们观察到了一个早期存在的深度模式，这个模式在成年人中也有观察到。结果还显示，在 12 个月大时，与口面部运动相关的位置存在右向深度不对称，这种不对称逐渐消失，主要在 12 到 24 个月之间，我们认为这与语言技能的发展有关。
