非整倍体在人类真菌病原体白色念珠菌棘白菌素耐药性产生中的作用。 - Suppr

The role of aneuploidy in the emergence of echinocandin resistance in human fungal pathogen Candida albicans.

作者信息

Sah Sudisht Kumar, Hayes Jeffrey Joseph, Rustchenko Elena

机构信息

Department of Biochemistry and Biophysics, University of Rochester Medical Center, Rochester, New York, United States of America.

出版信息

PLoS Pathog. 2021 May 27;17(5):e1009564. doi: 10.1371/journal.ppat.1009564. eCollection 2021 May.

DOI:10.1371/journal.ppat.1009564

PMID:34043737

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8158998/

Abstract

摘要

相似文献

The role of aneuploidy in the emergence of echinocandin resistance in human fungal pathogen Candida albicans.非整倍体在人类真菌病原体白色念珠菌棘白菌素耐药性产生中的作用。

PLoS Pathog. 2021 May 27;17(5):e1009564. doi: 10.1371/journal.ppat.1009564. eCollection 2021 May.

Chromosome 5 of Human Pathogen Candida albicans Carries Multiple Genes for Negative Control of Caspofungin and Anidulafungin Susceptibility.人类病原体白色念珠菌的5号染色体携带多个用于负调控卡泊芬净和阿尼芬净敏感性的基因。

Antimicrob Agents Chemother. 2016 Nov 21;60(12):7457-7467. doi: 10.1128/AAC.01888-16. Print 2016 Dec.

Generation of mutants in Candida albicans with reduced susceptibility to caspofungin: influence on other antifungal products.白色念珠菌中对卡泊芬净敏感性降低的突变体的产生：对其他抗真菌药物的影响。

J Chemother. 2010 Aug;22(4):283-4. doi: 10.1179/joc.2010.22.4.283.

First Case of Echinocandin-Resistant Candida albicans in Korea.韩国首例对棘白菌素耐药的白色念珠菌病例。

Ann Lab Med. 2017 Nov;37(6):556-558. doi: 10.3343/alm.2017.37.6.556.

Effects of Echinocandins in Combination with Nikkomycin Z against Invasive Candida albicans Bloodstream Isolates and the Mutants.棘白菌素类药物联合尼可霉素 Z 对侵袭性白念珠菌血流分离株及其突变株的作用。

Antimicrob Agents Chemother. 2017 Oct 24;61(11). doi: 10.1128/AAC.00619-17. Print 2017 Nov.

and Genes of Opportunistic Human Pathogen Candida albicans Influence Echinocandin Susceptibility.并且，机会性人类病原体白念珠菌的基因影响棘白菌素类药物的敏感性。

Antimicrob Agents Chemother. 2018 Mar 27;62(4). doi: 10.1128/AAC.02299-17. Print 2018 Apr.

Accuracy of Sensititre YeastOne echinocandins epidemiological cut-off values for identification of FKS mutant Candida albicans and Candida glabrata: a ten year national survey of the Fungal Infection Network of Switzerland (FUNGINOS).Sensititre YeastOne 棘白菌素药敏试验流行病学折点用于鉴定 FKS 突变的白念珠菌和光滑念珠菌的准确性：瑞士真菌感染网络（FUNGINOS）的十年全国调查。

Clin Microbiol Infect. 2018 Nov;24(11):1214.e1-1214.e4. doi: 10.1016/j.cmi.2018.05.012. Epub 2018 Jun 15.

Tolerance to Caspofungin in Candida albicans Is Associated with at Least Three Distinctive Mechanisms That Govern Expression of Genes and Cell Wall Remodeling.白色念珠菌对卡泊芬净的耐受性与至少三种控制基因表达和细胞壁重塑的独特机制有关。

Antimicrob Agents Chemother. 2017 Apr 24;61(5). doi: 10.1128/AAC.00071-17. Print 2017 May.

Fungal echinocandin resistance.真菌棘白菌素耐药性。

Fungal Genet Biol. 2010 Feb;47(2):117-26. doi: 10.1016/j.fgb.2009.09.003. Epub 2009 Sep 19.

Molecular Detection of Resistance to Echinocandins.棘白菌素耐药性的分子检测

Methods Mol Biol. 2017;1508:413-421. doi: 10.1007/978-1-4939-6515-1_23.

引用本文的文献

Insight into the Mechanisms and Clinical Relevance of Antifungal Heteroresistance.深入了解抗真菌异质性耐药的机制及临床相关性。

J Fungi (Basel). 2025 Feb 13;11(2):143. doi: 10.3390/jof11020143.

Echinocandin Adaptation in Is Accompanied by Altered Chromatin Accessibility at Gene Promoters and by Cell Wall Remodeling.棘白菌素适应性伴随着基因启动子处染色质可及性的改变以及细胞壁重塑。

J Fungi (Basel). 2025 Feb 1;11(2):110. doi: 10.3390/jof11020110.

The Microevolution of Antifungal Drug Resistance in Pathogenic Fungi.致病真菌中抗真菌药物耐药性的微观进化

Microorganisms. 2023 Nov 13;11(11):2757. doi: 10.3390/microorganisms11112757.

Tetraploidy accelerates adaptation under drug selection in a fungal pathogen.四倍体在真菌病原体的药物选择下加速适应性。

Front Fungal Biol. 2022 Nov 16;3:984377. doi: 10.3389/ffunb.2022.984377. eCollection 2022.

Genome-Wide DNA Changes Acquired by Caspofungin-Adapted Mutants.卡泊芬净适应性突变体获得的全基因组DNA变化

Microorganisms. 2023 Jul 25;11(8):1870. doi: 10.3390/microorganisms11081870.

Life in plastic, it's fantastic! How exploit genome instability to shape gene expression.塑料生活，奇妙无比！如何利用基因组不稳定性来塑造基因表达。

Front Cell Infect Microbiol. 2023 Jan 26;13:1102462. doi: 10.3389/fcimb.2023.1102462. eCollection 2023.

Strains Adapted to Caspofungin Due to Aneuploidy Become Highly Tolerant under Continued Drug Pressure.由于非整倍体而适应卡泊芬净的菌株在持续的药物压力下变得高度耐受。

Microorganisms. 2022 Dec 21;11(1):23. doi: 10.3390/microorganisms11010023.

Multiple Genes of Candida albicans Influencing Echinocandin Susceptibility in Caspofungin-Adapted Mutants.白念珠菌多个基因影响棘白菌素适应突变株的敏感性。

Antimicrob Agents Chemother. 2022 Dec 20;66(12):e0097722. doi: 10.1128/aac.00977-22. Epub 2022 Nov 10.

Aneuploidy Underlies Tolerance and Cross-Tolerance to Drugs in Candida parapsilosis.非整倍性是假丝酵母对药物的耐受性和交叉耐受性的基础。

Microbiol Spectr. 2021 Oct 31;9(2):e0050821. doi: 10.1128/Spectrum.00508-21. Epub 2021 Oct 6.

Tunicamycin Potentiates Antifungal Drug Tolerance via Aneuploidy in Candida albicans.衣霉素通过增加白念珠菌非整倍体增强抗真菌药物耐受性。

mBio. 2021 Aug 31;12(4):e0227221. doi: 10.1128/mBio.02272-21.

本文引用的文献

CSU57 encodes a novel repressor of sorbose utilization in opportunistic human fungal pathogen Candida albicans.CSU57 编码了一种新型的蔗糖利用抑制剂，在机会性人类真菌病原体白念珠菌中。

Yeast. 2021 Mar;38(3):222-238. doi: 10.1002/yea.3537. Epub 2020 Dec 29.

Aneuploidy Enables Cross-Adaptation to Unrelated Drugs.非整倍体使对不相关药物的交叉适应成为可能。

Mol Biol Evol. 2019 Aug 1;36(8):1768-1782. doi: 10.1093/molbev/msz104.

The Still Underestimated Problem of Fungal Diseases Worldwide.全球范围内仍被低估的真菌病问题。

Front Microbiol. 2019 Feb 12;10:214. doi: 10.3389/fmicb.2019.00214. eCollection 2019.

Fungal Resistance to Echinocandins and the MDR Phenomenon in .真菌对棘白菌素的耐药性及多重耐药现象

J Fungi (Basel). 2018 Sep 1;4(3):105. doi: 10.3390/jof4030105.

Functional Genomic Screening Reveals Core Modulators of Echinocandin Stress Responses in Candida albicans.功能基因组筛选揭示白念珠菌中棘白菌素应激反应的核心调节剂。

Cell Rep. 2018 May 22;23(8):2292-2298. doi: 10.1016/j.celrep.2018.04.084.

Transcriptional Regulation on Aneuploid Chromosomes in Divers Candida albicans Mutants.转录调控在不同的白念珠菌突变体的非整倍体染色体。

Sci Rep. 2018 Jan 26;8(1):1630. doi: 10.1038/s41598-018-20106-9.

and Genes of Opportunistic Human Pathogen Candida albicans Influence Echinocandin Susceptibility.并且，机会性人类病原体白念珠菌的基因影响棘白菌素类药物的敏感性。

Antimicrob Agents Chemother. 2018 Mar 27;62(4). doi: 10.1128/AAC.02299-17. Print 2018 Apr.

NuA4 histone acetyltransferase activity is required for H4 acetylation on a dosage-compensated monosomic chromosome that confers resistance to fungal toxins.在一条赋予对真菌毒素抗性的剂量补偿单染色体上，H4乙酰化需要NuA4组蛋白乙酰转移酶活性。

Epigenetics Chromatin. 2017 Oct 23;10(1):49. doi: 10.1186/s13072-017-0156-y.

Disarming Fungal Pathogens: Inhibits Virulence Factor Production and Biofilm Formation by and .解除真菌病原体的武装：抑制和的毒力因子产生和生物膜形成。

mBio. 2017 Oct 3;8(5):e01537-17. doi: 10.1128/mBio.01537-17.

Antimicrob Agents Chemother. 2017 Apr 24;61(5). doi: 10.1128/AAC.00071-17. Print 2017 May.

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

The role of aneuploidy in the emergence of echinocandin resistance in human fungal pathogen Candida albicans.

作者信息

机构信息

出版信息

相似文献

引用本文的文献

本文引用的文献

文献检索

文件翻译

深度研究

Suppr 超能文献

相似文献

引用本文的文献

本文引用的文献