[炎症反应在增生性瘢痕和瘢痕疙瘩形成中的作用及机制的研究进展]
[Research advances on the role and mechanism of inflammatory response in the formation of hypertrophic scars and keloids].
作者信息
Wang H T, Han J T, Hu D H
机构信息
Department of Burns and Cutaneous Surgery, Burn Center of PLA, the First Affiliated Hospital of Air Force Medical University, Xi'an 710032, China.
出版信息
Zhonghua Shao Shang Za Zhi. 2021 May 20;37(5):490-494. doi: 10.3760/cma.j.cn501120-20200310-00143.
Hypertrophic scars and keloids are common sequelae after wound healing, with a high incidence, which seriously affect the patient's quality of life. However, there is still a lack of effective prevention and treatment methods, mainly because the pathogenesis of scars is not clear. Current research believe that inflammatory response plays a critical role in the process of scar formation, and through the researches on the mechanisms it is hopeful to find new potential therapeutic drug targets for the prevention and treatment of hypertrophic scars and keloids. This article mainly reviews the research progresses on the role and mechanism of inflammatory cytokines and inflammatory cells in the formation of hypertrophic scars and keloids, as well as drugs, microRNAs, and exosomes, etc., for the treatment of hypertrophic scars and keloids by inhibiting inflammatory response.
增生性瘢痕和瘢痕疙瘩是伤口愈合后的常见后遗症，发病率高，严重影响患者的生活质量。然而，目前仍缺乏有效的防治方法，主要原因是瘢痕的发病机制尚不清楚。目前的研究认为，炎症反应在瘢痕形成过程中起关键作用，通过对其机制的研究，有望找到预防和治疗增生性瘢痕和瘢痕疙瘩的新的潜在治疗药物靶点。本文主要综述了炎症细胞因子和炎症细胞在增生性瘢痕和瘢痕疙瘩形成中的作用及机制的研究进展，以及通过抑制炎症反应治疗增生性瘢痕和瘢痕疙瘩的药物、微小RNA和外泌体等。
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