Laboratory and Pathology, Shaanxi Corps Hospital of Chinese People's Armed Police Forces, Xi'an, China.
Department of Laboratory, Jiamusi Hospital of Traditional Chinese Medicine, Jiamusi, China.
Ann Palliat Med. 2021 May;10(5):5329-5340. doi: 10.21037/apm-21-840. Epub 2021 May 17.
Procalcitonin (PCT) can effectively identify bacterial infections and can be used for risk prediction and antimicrobial treatment in patients with unexplained fever and critically ill patients. In this study, statistical analyses of the literature were performed to clarify the application and research status of PCT in respiratory diseases. Future research directions are discussed.
A literature search was conducted using the Science Citation Index Expanded (SCI-EXPANDED) database in the Web of Science Core Collection (WOSCC). Published literature between 1995 and February 6, 2021 were searched using the following strategies: subject term = procalcitonin; and Web of Science categories = Respiratory System. Using the Citespace software, the literature on the application of PCT in patients with respiratory diseases was analyzed in terms of annual publication status, subject distribution, country/institution distribution, journal distribution, author distribution, and keywords.
A total of 542 related research literatures were identified, with the number of published papers and the number of literature citations increasing yearly. Research was mainly concentrated in the United States, China, Switzerland, and other countries, with countries such as the United Kingdom, the United States, and Canada being involved in international collaborations. Research institutions were mainly universities or hospitals such as the University Hospital of Basel, University of Barcelona, and Northwestern University. In particular, the University Hospital of Basel had extensive inter-hospital collaborations. Stolz et al. published many related papers, but the centrality value was low. Authors including Christ-Crain M, Schuetz P, and Stolz D were highly cited. Journals such as the American Journal of Respiratory and Critical Care Medicine, Chest, and the European Respiratory Journal were more influential. Keyword analysis showed that sepsis and pneumonia are the current hot topics.
Related papers mainly focused on respiratory infections, especially sepsis and pneumonia. There were also a small number of studies suggesting that PCT is related to tumors.
降钙素原（PCT）可有效鉴别细菌感染，并可用于不明原因发热和危重症患者的风险预测和抗菌治疗。本研究通过文献统计学分析，阐明 PCT 在呼吸系统疾病中的应用和研究现状，并探讨未来研究方向。
通过 Web of Science 核心合集（WOSCC）中的科学引文索引扩展（SCI-EXPANDED）数据库进行文献检索，使用主题词=降钙素原，以及 Web of Science 类别=呼吸系统进行检索，检索 1995 年至 2021 年 2 月 6 日期间发表的文献。使用 Citespace 软件对 PCT 在呼吸系统疾病患者中的应用文献进行年度发文量、主题分布、国家/机构分布、期刊分布、作者分布和关键词分析。
共纳入 542 篇相关研究文献，发文量和文献被引频次逐年增加。研究主要集中在美国、中国、瑞士等国家，英国、美国、加拿大等国家也有国际合作。研究机构主要为大学或医院，如巴塞尔大学医院、巴塞罗那大学、西北大学等，其中巴塞尔大学医院的院内合作较为广泛。Stolz 等发表了较多相关论文，但中心性值较低。Christ-Crain M、Schuetz P、Stolz D 等作者的被引频次较高。期刊方面，《美国呼吸与危重症医学杂志》《胸部》《欧洲呼吸杂志》等期刊影响力较大。关键词分析显示，目前的研究热点为脓毒症和肺炎，也有少数研究提示 PCT 与肿瘤有关。
相关文献主要集中于呼吸系统感染，尤其是脓毒症和肺炎，也有少数研究提示 PCT 与肿瘤有关。
