Department of Biomedical Sciences, 14681University of Illinois College of Medicine, Rockford, IL, USA.
Nutr Health. 2022 Jun;28(2):207-212. doi: 10.1177/02601060211018360. Epub 2021 May 28.
Therapy resistance is the underlying reason for poor outcome in prostate cancer (PCa) patients. Diallyl trisulfide (DATS) is an organosulfur compound present in garlic. DATS has been shown to target PCa cells by induction of apoptosis, increase in the production of reactive oxygen species, degradation of ferritin protein and increase in the labile iron (Fe) pool.
We hypothesize that DATS could induce ferroptosis, an Fe-dependent, unique non-apoptotic form of regulated cell death to eliminate therapy resistance encountered by PCa patients.
and studies should be performed to test the hypothesis.
As per the hypothesis, DATS would eliminate apoptotic resistance via inducing ferroptosis.
Since apoptosis resistance has been reported to be the underlying mechanism of therapy resistance in PCa, DATS could be used to effectively target PCa cells by overcoming apoptosis resistance and inducing ferroptosis-mediated cell death of PCa cells.
治疗抵抗是前列腺癌（PCa）患者预后不良的根本原因。二烯丙基三硫（DATS）是大蒜中存在的一种有机硫化合物。研究表明，DATS 通过诱导细胞凋亡、增加活性氧的产生、降解铁蛋白和增加不稳定铁（Fe）池来靶向 PCa 细胞。
我们假设 DATS 可以诱导铁死亡，这是一种 Fe 依赖性的、独特的非凋亡形式的细胞死亡，以消除 PCa 患者遇到的治疗抵抗。
应进行研究来验证该假说。
根据假设，DATS 将通过诱导铁死亡来消除细胞凋亡抵抗。
由于细胞凋亡抵抗已被报道是 PCa 治疗抵抗的潜在机制，因此 DATS 可通过克服细胞凋亡抵抗并诱导铁死亡介导的 PCa 细胞死亡来有效靶向 PCa 细胞。
