Liang Jiaming, Liao Yihao, Wang Pu, Yang Kun, Wang Youzhi, Wang Keke, Zhong Boqiang, Zhou Diansheng, Cao Qian, Li Junbo, Zhao Yang, Jiang Ning
Tianjin institute of Urology, The Second Hospital of Tianjin Medical University, 300211, Tianjin, China.
School of Future Technology, Xi'an Jiaotong University, 710049, Xi'an, Shaanxi, China.
Cell Death Discov. 2023 Apr 15;9(1):128. doi: 10.1038/s41420-023-01430-0.
Prostate cancer is a major disease that threatens men's health. Its rapid progression, easy metastasis, and late castration resistance have brought obstacles to treatment. It is necessary to find new effective anticancer methods. Ferroptosis is a novel iron-dependent programmed cell death that plays a role in various cancers. Understanding how ferroptosis is regulated in prostate cancer will help us to use it as a new way to kill cancer cells. In this review, we summarize the regulation and role of ferroptosis in prostate cancer and the relationship with AR from the perspective of metabolism and molecular pathways. We also discuss the feasibility of ferroptosis in prostate cancer treatment and describe current limitations and prospects, providing a reference for future research and clinical application of ferroptosis.
前列腺癌是一种威胁男性健康的主要疾病。其进展迅速、易于转移且后期出现去势抵抗，给治疗带来了障碍。有必要寻找新的有效抗癌方法。铁死亡是一种新型的铁依赖性程序性细胞死亡，在多种癌症中发挥作用。了解前列腺癌中铁死亡是如何被调控的，将有助于我们将其作为一种杀死癌细胞的新方法。在这篇综述中，我们从代谢和分子途径的角度总结了铁死亡在前列腺癌中的调控、作用以及与雄激素受体（AR）的关系。我们还讨论了铁死亡在前列腺癌治疗中的可行性，并描述了当前的局限性和前景，为铁死亡的未来研究和临床应用提供参考。
