Zoratto N, Montanari E, Viola M, Wang J, Coviello T, Di Meo C, Matricardi P
Department of Drug Chemistry and Technologies, Sapienza University of Rome, 00185 Roma, Italy.
Institute of Pharmaceutical Sciences, Department of Chemistry and Applied Biosciences, ETH Zurich, 8093 Zurich, Switzerland.
Carbohydr Polym. 2021 Aug 15;266:118119. doi: 10.1016/j.carbpol.2021.118119. Epub 2021 Apr 28.
Nowadays nanoparticles are increasingly investigated for the targeted and controlled delivery of therapeutics, as suggested by the high number of research articles (2400 in 2000 vs 8500 in 2020). Among them, almost 2% investigated nanogels in 2020. Nanogels or nanohydrogels (NGs) are nanoparticles formed by a swollen three-dimensional network of synthetic polymers or natural macromolecules such as polysaccharides. NGs represent a highly versatile nanocarrier, able to deliver a number of therapeutics. Currently, NGs are undergoing clinical trials for the delivery of anti-cancer vaccines. Herein, the strategies to load low molecular weight drugs, (poly)peptides and genetic material into polysaccharide NGs as well as to formulate NGs-based vaccines are summarized, with a focus on the microfluidics approach.
如今，纳米颗粒越来越多地被用于治疗药物的靶向和控释，这从大量的研究文章中可见一斑（2000年有2400篇，而2020年有8500篇）。其中，2020年有近2%的研究涉及纳米凝胶。纳米凝胶或纳米水凝胶（NGs）是由合成聚合物或天然大分子（如多糖）的溶胀三维网络形成的纳米颗粒。NGs是一种高度通用的纳米载体，能够递送多种治疗药物。目前，NGs正在进行抗癌疫苗递送的临床试验。本文总结了将低分子量药物、（多）肽和遗传物质负载到多糖NGs中的策略以及基于NGs的疫苗的制备方法，重点是微流控方法。
