Department of Pharmaceutics, National Institute of Pharmaceutical Education and Research (NIPER-HYD), Balanagar, Telangana, India.
Department of Medicinal Chemistry, National Institute of Pharmaceutical Education and Research (NIPER-HYD), Balanagar, Telangana, India.
Int J Pharm. 2020 May 15;581:119268. doi: 10.1016/j.ijpharm.2020.119268. Epub 2020 Mar 30.
Nanogels, also known as next generation drug delivery systems are in the limelight of the research owing to their advantages like high loading, tunability of size, stimuli responsiveness, sustained drug release via in situ gelling mechanisms, stability, etc. Nanogels have proven to be superior in terms of reducing the complexities involved in this delivery system overcoming the drawbacks of the conventional approaches. This review will give readers an in depth understanding about basics of nanogel, classification, synthesis, advances in nanogel technology, mechanisms involved, regulatory considerations and the opportunities for further exploration in order to achieve high therapeutic efficacy for fatal diseases.
纳米凝胶，也被称为下一代药物传递系统，由于其具有高载药量、可调节粒径、对刺激的响应性、通过原位凝胶机制的药物持续释放、稳定性等优点，成为研究的焦点。纳米凝胶已被证明在降低这一传递系统的复杂性方面具有优势，克服了传统方法的缺点。本综述将使读者深入了解纳米凝胶的基础知识、分类、合成、纳米凝胶技术的进展、涉及的机制、监管考虑因素以及进一步探索的机会，以实现致命疾病的高治疗效果。
