State Key Laboratory of Metal Matrix Composites, Shanghai Jiao Tong University, Shanghai 200240, People's Republic of China.
Department of Ophthalmology, Ninth People's Hospital, Shanghai Jiao Tong University, Shanghai 200240, People's Republic of China.
Carbohydr Polym. 2021 Aug 15;266:118122. doi: 10.1016/j.carbpol.2021.118122. Epub 2021 Apr 27.
Hydrogels often have poor mechanical properties which limit their application in load-bearing tissues such as muscle and cartilage. In this work, a near-infrared light-triggered stretchable thermal-sensitive hydrogel with ultra-high drug loading was developed by a combination of natural polymeric nanocrystals, a network of synthetic thermo-responsive polymer, and magnetic FeO nanoparticles. The hydrogels comprise cellulose nanocrystals (CNCs) decorated with FeO nanoparticles (FeO/CNCs) dispersed homogeneously in poly(N-isopropylacrylamide) (PNIPAm) networks. The composite hydrogels exhibit an extensibility of 2200%. Drug loading of vancomycin (VCM) reached a high value of 10.18 g g due to the dispersion of FeO/CNCs and the interactions between the CNCs and the PNIPAm network. Importantly, the hydrogels demonstrated a thermo-response triggered by NIR, with the temperature increasing from 26 to 41 °C within 60 s. The hydrogels have high biocompatibility evidenced by cell proliferation tests, illustrating that these hydrogels are promising as dressings for wound closure, and wound healing.
水凝胶通常具有较差的机械性能，这限制了它们在承重组织如肌肉和软骨中的应用。在这项工作中，通过天然聚合物纳米晶体、合成温敏聚合物网络和磁性 FeO 纳米粒子的组合，开发了一种近红外光触发的可拉伸热敏感水凝胶，具有超高的药物负载。水凝胶由 FeO 纳米粒子（FeO/CNCs）修饰的纤维素纳米晶体（CNCs）均匀分散在聚（N-异丙基丙烯酰胺）（PNIPAm）网络中。该复合材料水凝胶的可拉伸性达到 2200%。由于 FeO/CNCs 的分散和 CNCs 与 PNIPAm 网络之间的相互作用，万古霉素（VCM）的药物负载达到了 10.18 g/g 的高值。重要的是，水凝胶表现出近红外触发的热响应，在 60 秒内温度从 26 升高到 41°C。水凝胶具有高生物相容性，这可通过细胞增殖试验证明，这表明这些水凝胶有望用作伤口闭合和伤口愈合的敷料。
