School of Chemical Engineering, Yeungnam University, 280-Daehak-Ro, Gyeongsan 712-749, South Korea.
School of Chemical Engineering, Yeungnam University, 280-Daehak-Ro, Gyeongsan 712-749, South Korea.
Int J Biol Macromol. 2017 Aug;101:165-171. doi: 10.1016/j.ijbiomac.2017.03.080. Epub 2017 Mar 18.
Cellulose nanocrystals (CNCs) reinforced, bionanocomposite (BNC) has shown great potential in tissue engineering and drug delivery applications due to the low toxicity, low density, and high aspect ratio. In this work, BNC hydrogels reinforced with CNCs were fabricated from xanthan (XG) solutions and chitosan (CS) in presence of green acidifying agent through electrostatic and hydrogen bonding interactions. As developed BNC hydrogels were characterized for complex formation, morphology, and mechanical behavior. The mechanical performance of BNC hydrogels was improved significantly as increased CNC content (from 2 to 10wt%). 5-Flurouracil as model chemotherapeutic agent was loaded into these BNC hydrogels for evaluating their drug release properties. The BNC hydrogels showed excellent cytocompatability and ability to release of chemotherapeutic agent that shows the suitability to be used in tissue engineering as well as drug delivery applications.
纤维素纳米晶体（CNCs）增强的生物纳米复合材料（BNC）由于低毒性、低密度和高纵横比，在组织工程和药物输送应用中显示出巨大的潜力。在这项工作中，通过静电和氢键相互作用，从黄原胶（XG）溶液和壳聚糖（CS）中制备了增强纤维素纳米晶体（CNCs）的 BNC 水凝胶，使用绿色酸化剂。所开发的 BNC 水凝胶的复杂形成、形态和机械行为进行了表征。随着 CNC 含量的增加（从 2 到 10wt%），BNC 水凝胶的机械性能显著提高。将 5-氟尿嘧啶作为模型化疗药物载入这些 BNC 水凝胶中，以评估其药物释放性能。BNC 水凝胶显示出优异的细胞相容性和化疗药物释放能力，这表明它们适合用于组织工程和药物输送应用。
