Carney R M, Rich M W, teVelde A, Saini J, Clark K, Freedland K E
Department of Psychiatry, Washington University School of Medicine, St. Louis, MO.
J Psychosom Res. 1988;32(2):159-64. doi: 10.1016/0022-3999(88)90050-5.
Seventy-seven patients undergoing elective cardiac catheterization were administered a diagnostic psychiatric interview and their mean heart rates and heart rate variability were determined from the results of a 24 hr ambulatory ECG. The mean heart rate for depressed patients with coronary artery disease (CAD) was significantly higher than for nondepressed CAD patients, independent of the patient's age, smoking status, and beta blocker therapy. Heart rate variability was lower in depressed patients but did not achieve significance. With the exception of smoking, which was more common in depressed patients, there were no significant differences between the depressed and nondepressed patients on any other medical or demographic variable assessed. It is concluded that elevated heart rate may represent increased sympathetic tone in depressed CAD patients, and may help to explain the increased morbidity and mortality reported in these patients.
对77例接受择期心导管插入术的患者进行了诊断性精神科访谈，并根据24小时动态心电图结果测定了他们的平均心率和心率变异性。患有冠状动脉疾病（CAD）的抑郁症患者的平均心率显著高于非抑郁症CAD患者，且不受患者年龄、吸烟状况和β受体阻滞剂治疗的影响。抑郁症患者的心率变异性较低，但未达到显著水平。除了吸烟在抑郁症患者中更常见外，在评估的任何其他医学或人口统计学变量上，抑郁症患者和非抑郁症患者之间没有显著差异。研究得出结论，心率升高可能代表抑郁症CAD患者交感神经张力增加，这可能有助于解释这些患者报告的发病率和死亡率增加的原因。
