Krittayaphong R, Cascio W E, Light K C, Sheffield D, Golden R N, Finkel J B, Glekas G, Koch G G, Sheps D S
Division of Cardiology, University of North Carolina Schools of Medicine, Chapel Hill, USA.
Psychosom Med. 1997 May-Jun;59(3):231-5. doi: 10.1097/00006842-199705000-00004.
This study tested the hypothesis that coronary artery disease patients with higher depression scores have lower heart rate variability during daily life.
Thirty-three men and nine women, ranging in age from 46 to 79, with coronary artery disease and exercise-induced ischemia were studied. The standard deviation of normal R-R intervals (SDNN) and average heart rate were obtained from 24-hour ambulatory electrocardiographic monitoring. Patients were grouped by a median split of the Minnesota Multiphasic Personality Inventory (MMPI-D) score.
SDNN was lower (p = .009) and average heart rate was higher (p = .003) in patients with higher depression scores. These relationships remained substantially unaltered after statistically adjusting for the only demographic/clinical factor that varied between the groups: gender.
In comparison to the lower depression score group, those with higher depression scores had lower heart rate variability during daily life. These findings may be related to the reported relationship between depression and survival risk in patients with coronary artery disease.
本研究检验了以下假设，即抑郁评分较高的冠心病患者在日常生活中的心率变异性较低。
对33名男性和9名女性进行了研究，他们年龄在46至79岁之间，患有冠心病且有运动诱发的缺血。通过24小时动态心电图监测获取正常R-R间期的标准差（SDNN）和平均心率。患者根据明尼苏达多相人格调查表（MMPI-D）得分的中位数划分进行分组。
抑郁评分较高的患者SDNN较低（p = 0.009），平均心率较高（p = 0.003）。在对两组之间唯一不同的人口统计学/临床因素：性别进行统计学调整后，这些关系基本保持不变。
与抑郁评分较低的组相比，抑郁评分较高的组在日常生活中的心率变异性较低。这些发现可能与报道的冠心病患者抑郁与生存风险之间的关系有关。
