Okoye M I, Watanabe I
J Natl Med Assoc. 1988 Jul;80(7):770-5.
The giant cells of histologically typical cases of nodular fasciitis were studied by electron microscopy and immunohistochemistry. Ultrastructurally, these cells were found to be similar to the adjacent spindle and large fibroblast-like cells in many ways. These giant cells exhibited numerous intracytoplasmic, well-formed longitudinally oriented bundles of myofilaments and hemi-desmosome-like structures with associated basement membrane-like material, abundant endoplasmic reticulum, and numerous dense bodies. The observed myofilaments did not show beading or Z-line formation. Immunohistochemical staining by means of the indirect peroxidase-antiperoxidase technique failed to localize the proven antigenic markers of histiocytes within the giant cells. The results support the concept that the giant cells in nodular fasciitis are of myofibroblastic origin. It is thus proposed that these giant cells are neither histiocytes nor rhabdomyoblasts as previously thought, but are rather modified fibroblasts ("myofibroblasts").
通过电子显微镜和免疫组织化学对结节性筋膜炎组织学典型病例中的巨细胞进行了研究。在超微结构上，发现这些细胞在许多方面与相邻的梭形和大的成纤维细胞样细胞相似。这些巨细胞表现出许多胞质内、结构良好的纵向排列的肌丝束以及半桥粒样结构和相关的基底膜样物质、丰富的内质网和大量致密小体。观察到的肌丝未显示出串珠状或Z线形成。通过间接过氧化物酶-抗过氧化物酶技术进行的免疫组织化学染色未能在巨细胞内定位已证实的组织细胞抗原标志物。结果支持结节性筋膜炎中的巨细胞起源于肌成纤维细胞的概念。因此，有人提出这些巨细胞既不是先前认为的组织细胞也不是成横纹肌细胞，而是经过修饰的成纤维细胞（“肌成纤维细胞”）。
