Jia Yaqi, Huang Tao
Department of Hepatobiliary Surgery, The Affiliated Cancer Hospital of Zhengzhou University, Zhengzhou, People's Republic of China.
Cancer Manag Res. 2021 May 20;13:4095-4101. doi: 10.2147/CMAR.S308168. eCollection 2021.
Antabuse, generic name disulfiram, has been extensively used in daily clinical practice to treat alcohol abuse. In vivo and in vitro experiments have demonstrated that disulfiram was capable of inhibiting tumor cell proliferation; clinical studies have indicated that the administration of this drug was associated with favorable survival, whilst in vitro experiments have elucidated the anticancer mechanism of disulfiram. In addition, radiation and cancer biology studies have shown that disulfiram can protect normal cells and sensitize tumor cells during radiotherapy. This review aims at describing the antitumor activity of disulfiram in both preclinical studies and clinical trials, whilst focusing on the advances of this drug in radiation and cancer biology, and the promise of repurposing it as a novel sensitizer to, and protector against, radiation on the incoming clinical studies.
安塔布司，通用名为双硫仑，已在日常临床实践中广泛用于治疗酒精滥用。体内和体外实验均表明双硫仑能够抑制肿瘤细胞增殖；临床研究表明，使用该药物与良好的生存率相关，而体外实验阐明了双硫仑的抗癌机制。此外，放射生物学和癌症生物学研究表明，双硫仑在放疗期间可保护正常细胞并使肿瘤细胞敏感化。本综述旨在描述双硫仑在临床前研究和临床试验中的抗肿瘤活性，同时关注该药物在放射生物学和癌症生物学方面的进展，以及将其重新用作新型放疗增敏剂和放射防护剂在即将开展的临床研究中的前景。
