Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Peking University Cancer Hospital & Institute, No. 52, Fucheng Road, Haidian District, Beijing, 100142, China.
The Second Affiliated Hospital of Zhejiang University School of Medicine, No. 88, Jiefang Road, Hangzhou, Zhejiang, China.
J Hematol Oncol. 2019 Feb 14;12(1):16. doi: 10.1186/s13045-019-0702-0.
The lungs are the second most common site of metastasis for colorectal cancer (CRC) after the liver. Rectal cancer is associated with a higher incidence of lung metastases compared to colon cancer. In China, the proportion of rectal cancer cases is around 50%, much higher than that in Western countries (nearly 30%). However, there is no available consensus or guideline focusing on CRC with lung metastases. We conducted an extensive discussion and reached a consensus of management for lung metastases in CRC based on current research reports and the experts' clinical experiences and knowledge. This consensus provided detailed approaches of diagnosis and differential diagnosis and provided general guidelines for multidisciplinary therapy (MDT) of lung metastases. We also focused on recommendations of MDT management of synchronous lung metastases and initial metachronous lung metastases. This consensus might improve clinical practice of CRC with lung metastases in China and will encourage oncologists to conduct more clinical trials to obtain high-level evidences about managing lung metastases.
肺是结直肠癌（CRC）继肝之后第二常见的转移部位。与结肠癌相比，直肠癌与更高的肺转移发生率相关。在中国，直肠癌病例的比例约为 50%，远高于西方国家（近 30%）。然而，目前尚无针对 CRC 伴肺转移的共识或指南。我们根据目前的研究报告以及专家的临床经验和知识，对 CRC 伴肺转移进行了广泛的讨论，并达成了共识。该共识为 CRC 肺转移的诊断和鉴别诊断提供了详细的方法，并为多学科治疗（MDT）肺转移提供了一般指南。我们还重点关注了同步肺转移和初始异时性肺转移的 MDT 管理建议。该共识可能会改善中国 CRC 伴肺转移的临床实践，并鼓励肿瘤学家开展更多临床试验，以获得关于管理肺转移的高级别证据。
