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1例肝细胞癌放疗所致难治性食管溃疡

A Case of Refractory Esophageal Ulcer Caused by Radiotherapy for Hepatocellular Carcinoma.

作者信息

Hamada Kazu, Itoh Tohru, Kawaura Ken, Kuno Hiroaki, Kamai Junji, Kobayasi Rika, Azukisawa Sadahumi, Kitakata Hidekazu, Ishisaka Taishi, Igarashi Yuta, Kodera Kumie, Okuno Tazuo, Morita Takuro, Himeno Tarou, Yano Hiroshi, Higashikawa Toshihiro, Iritani Osamu, Iwai Kunimitsu, Morimoto Shigeto, Matoba Munetaka, Okuro Masashi

机构信息

Department of Geriatric Medicine, Kanazawa Medical University, Ishikawa, Japan.

Department of Gastroenterological Endoscopy, Kanazawa Medical University, Ishikawa, Japan.

出版信息

World J Oncol. 2021 Jun;12(2-3):67-72. doi: 10.14740/wjon1370. Epub 2021 May 14.

DOI:10.14740/wjon1370
PMID:34046101
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8139740/
Abstract

A 77-year-old man who underwent radiotherapy for hepatocellular carcinoma 6 months prior consulted for esophageal obstruction. Esophagogastroduodenoscopy revealed an esophageal ulcer caused by radiotherapy for hepatocellular carcinoma. He was treated with dietary counseling and vonoprazan. After 9 months, the ulcer improved but a moderate stenosis remained. Several factors such as high fraction size, history of chemotherapy, and stress associated with food intake might involve in the development of a radiation-associated ulcer. Opportunities to choose radiotherapy for hepatocellular carcinoma may increase, so we hypothesize that esophageal ulcers might be a complication that should be noted associated with this therapy.

摘要

一名77岁男性，6个月前因肝细胞癌接受放疗，现因食管梗阻前来咨询。食管胃十二指肠镜检查显示为肝细胞癌放疗所致的食管溃疡。对其进行了饮食咨询和使用沃克（富马酸伏诺拉生片）治疗。9个月后，溃疡有所改善，但仍存在中度狭窄。高分次剂量、化疗史以及与食物摄入相关的压力等多种因素可能与放射性溃疡的发生有关。肝细胞癌选择放疗的机会可能会增加，因此我们推测食管溃疡可能是这种治疗应注意的一种并发症。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1353/8139740/75d641a6c8bd/wjon-12-067-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1353/8139740/294240efa60e/wjon-12-067-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1353/8139740/113048cfefa9/wjon-12-067-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1353/8139740/01ae1daa498b/wjon-12-067-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1353/8139740/a72063bee0e2/wjon-12-067-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1353/8139740/fb63ce62516a/wjon-12-067-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1353/8139740/96d50b67c007/wjon-12-067-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1353/8139740/75d641a6c8bd/wjon-12-067-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1353/8139740/294240efa60e/wjon-12-067-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1353/8139740/113048cfefa9/wjon-12-067-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1353/8139740/01ae1daa498b/wjon-12-067-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1353/8139740/a72063bee0e2/wjon-12-067-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1353/8139740/fb63ce62516a/wjon-12-067-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1353/8139740/96d50b67c007/wjon-12-067-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1353/8139740/75d641a6c8bd/wjon-12-067-g007.jpg

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本文引用的文献

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