Manniche Claus, Hall Gerard M
Department of Occupational & Environmental Medicine, Odense University Hospital, Institute of Clinical Research, University of Southern Denmark, Odense, Denmark.
Princess Grace Hospital, London, UK.
Future Sci OA. 2021 Apr 7;7(6):FSO703. doi: 10.2144/fsoa-2021-0026.
Chronic low back pain (CLBP) has consistently been associated with the longest number of years lived with a disability in global studies, while commonly used treatments for CLBP are largely ineffective. In 2013 a randomized, double-blind, controlled study demonstrated significant improvements in CLBP patients demonstrating Modic changes type 1 on their MRI scans and undergoing long-term oral antibiotic treatment (100 days). Much of the ensuing debate has focused on whether this was a true infection or contamination. Newer and more advanced technologies clearly point to an ongoing low-grade infection. We have reviewed all of the clinical trials published in the recent past and conclude that there is compelling evidence for the effect of long-term oral antibiotic treatment for this patient group.
慢性下腰痛（CLBP）在全球研究中一直与残疾生活年限最长相关，而CLBP常用治疗方法大多无效。2013年一项随机、双盲、对照研究表明，CLBP患者在MRI扫描显示有1型Modic改变并接受长期口服抗生素治疗（100天）后有显著改善。随后的许多争论集中在这是真正的感染还是污染。更新、更先进的技术明确指向存在持续的低度感染。我们回顾了近期发表的所有临床试验，得出结论：有令人信服的证据表明长期口服抗生素治疗对该患者群体有效。
