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化脓性汗腺炎与克罗恩病的关联。

Association of hidradenitis suppurativa with Crohn's disease.

作者信息

Zhang Meng, Chen Qun-De, Xu Hai-Xia, Xu Yu-Meng, Chen Hong-Jin, Yang Bo-Lin

机构信息

Department of Colorectal Surgery, TheAffiliated Hospital of Nanjing University of Chinese Medicine, Jiangsu Province Hospital of Chinese Medicine, Nanjing 210029, Jiangsu Province, China.

First Clinical Medical College, The Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing 210029, Jiangsu Province, China.

出版信息

World J Clin Cases. 2021 May 26;9(15):3506-3516. doi: 10.12998/wjcc.v9.i15.3506.

DOI:10.12998/wjcc.v9.i15.3506
PMID:34046451
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8130070/
Abstract

Hidradenitis suppurativa (HS) is a chronic inflammatory skin disorder characterized by recurrent nodules, abscesses, and sinus tracts. Crohn's disease (CD) is characterized by inflammation of the entire digestive tract and belongs to the group of inflammatory bowel diseases, and there are many extraintestinal manifestations, among which hidradenitis suppurativa is one of the rare extraintestinal manifestations. There appears to be a strong association between CD and HS based on clinical and histological similarities (sinus tract development, granulomatous inflammation, and scarring), intersections in pathogenesis (genetic loci, immune dysregulation mechanisms, and microbiome changes), and commonality in treatment. In this review, we summarize recent studies on the association between HS and CD.

摘要

化脓性汗腺炎（HS）是一种慢性炎症性皮肤病，其特征为反复发作的结节、脓肿和窦道。克罗恩病（CD）的特征是整个消化道的炎症，属于炎症性肠病，有许多肠外表现，其中化脓性汗腺炎是罕见的肠外表现之一。基于临床和组织学上的相似性（窦道形成、肉芽肿性炎症和瘢痕形成）、发病机制的交叉点（基因位点、免疫失调机制和微生物群变化）以及治疗上的共性，CD和HS之间似乎存在密切关联。在本综述中，我们总结了近期关于HS与CD关联的研究。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/98c4/8130070/56678a46f202/WJCC-9-3506-g006.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/98c4/8130070/830a43b4623f/WJCC-9-3506-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/98c4/8130070/5cbe06477961/WJCC-9-3506-g003.jpg
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本文引用的文献

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Dermatol Online J. 2019 Sep 15;25(9):13030/qt0hw2w4nr.
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Association of Hidradenitis Suppurativa With Inflammatory Bowel Disease: A Systematic Review and Meta-analysis.化脓性汗腺炎与炎症性肠病的关联：一项系统评价和荟萃分析。
JAMA Dermatol. 2019 Sep 1;155(9):1022-1027. doi: 10.1001/jamadermatol.2019.0891.
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TNF-α inhibitors in the treatment of hidradenitis suppurativa.
Clin Colon Rectal Surg. 2024 Apr 19;38(2):141-147. doi: 10.1055/s-0044-1786198. eCollection 2025 Mar.
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Skin as a Reflection of Gut Health: An Overview of Dermatological Manifestations in Primary Neoplastic and Autoimmune Gastrointestinal Disorders.皮肤作为肠道健康的反映：原发性肿瘤性和自身免疫性胃肠疾病的皮肤表现概述
Cureus. 2024 Oct 12;16(10):e71313. doi: 10.7759/cureus.71313. eCollection 2024 Oct.
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Challenges in the Management of Perianal Hidradenitis Suppurativa in an African American Male: A Case Report.一名非裔美国男性肛周化脓性汗腺炎的管理挑战：病例报告
Cureus. 2023 Sep 22;15(9):e45788. doi: 10.7759/cureus.45788. eCollection 2023 Sep.
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Front Med (Lausanne). 2023 Mar 23;10:1151370. doi: 10.3389/fmed.2023.1151370. eCollection 2023.
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A Controversial Relationship Between Crohn's Disease and Hidradenitis Suppurativa: A Case Series and Literature Review.克罗恩病与化脓性汗腺炎之间的争议性关系：病例系列及文献综述
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