Ishigaki H, Sutoh K, Fukushi A, Kudoh H, Suga M, Gasa K, Boku A, Takebe K, Sekine T
2nd Dept. of Pathology, Hirosaki Univ. School of Med.
Gan No Rinsho. 1988 Jul;34(8):1007-12.
An autopsy case of a 72-year-old woman who was determined as having had a parathyroid carcinoma with primary hyperparathyroidism is reported. On autopsy, a tumor, measuring 6 X 3 X 2 cm, was found beneath the left lobe of the thyroid gland, adherent to the left recurrent nerve and the trachea, though there was no metastasis evident. The tumor was found to be lobulated on cross section inspection. Histologically, the tumor cells were arranged in trabecular and in solid patterns with fibrous bands. A few tumor cells showed mitosis. Invasions to the capsules and the blood vessels were found present. Immunohistochemically, the parathyroid hormone was found positive in the cytoplasm of the tumor cells. Otitis fibrosa generalisata, metastatic calcification, acute pancreatitis, and core pulmonale also were observed.
报告了一例72岁女性尸检病例，该患者被确诊为患有甲状旁腺癌伴原发性甲状旁腺功能亢进。尸检时，在甲状腺左叶下方发现一个大小为6×3×2 cm的肿瘤，与左喉返神经和气管粘连，不过未发现明显转移。经横断面检查，肿瘤呈分叶状。组织学上，肿瘤细胞呈小梁状和实性排列，伴有纤维带。少数肿瘤细胞可见有丝分裂。发现存在对包膜和血管的侵犯。免疫组织化学检查发现肿瘤细胞胞质内甲状旁腺激素呈阳性。还观察到全身性纤维性骨炎、转移性钙化、急性胰腺炎和肺源性心脏病。
