Borges Ricardo, García Antonio G
Pharmacology Unit, Medical School, Universidad de La Laguna, 38200, La Laguna, Tenerife, Spain.
Departamento de Farmacología y Terapéutica, Instituto Fundación Teófilo Hernando, Universidad Autónoma de Madrid, Madrid, Spain.
Pflugers Arch. 2021 Jun;473(6):977-981. doi: 10.1007/s00424-021-02580-9. Epub 2021 May 27.
One hundred years ago, a 4-page paper published in the Pflüger's Archiv fűr die Gesamte Physiologie des Menschen und der Tiere dramatically changed our view on synaptic transmission. The paper reported an ingenious, yet straightforward experiment made by Professor Otto Loewi in 1920 and published in 1921, which constitutes the first clear-cut proof for the chemical nature of transmission of the nerve impulse from nerve to muscle. The approach to this experiment was, however, tortuous and long.
一百年前，一篇发表在《 Pflüger's Archiv fűr die Gesamte Physiologie des Menschen und der Tiere》上的4页论文极大地改变了我们对突触传递的看法。该论文报道了奥托·洛伊维教授在1920年进行并于1921年发表的一项巧妙而直接的实验，这是神经冲动从神经向肌肉传递的化学本质的首个明确证据。然而，这个实验的过程曲折且漫长。
