• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

离体心脏灌注实验模型的发展历程及其在理解心脏生理学方面的开创性作用。

History of the development of isolated heart perfusion experimental model and its pioneering role in understanding heart physiology.

作者信息

Leivaditis Vasileios, Mulita Francesk, Dahm Manfred, Grapatsas Konstantinos, Papatriantafyllou Athanasios, Bekou Eleni, Verras Georgios-Ioannis, Tasios Konstantinos, Tchabashvili Levan, Markakis Konstantinos, Lozos Vasileios, Koletsis Efstratios

机构信息

Department of Cardiothoracic and Vascular Surgery, Westpfalz Klinikum, Kaiserslautern, Germany.

Department of General Surgery, Patras University Hospital, Patras, Greece.

出版信息

Arch Med Sci Atheroscler Dis. 2024 May 29;9:e109-e121. doi: 10.5114/amsad/188270. eCollection 2024.

DOI:10.5114/amsad/188270
PMID:39086622
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11289247/
Abstract

The isolated heart perfusion model, a fundamental tool in cardiovascular research, has evolved significantly since its inception in the late 19 century. This review traces the development of the isolated heart model, from its early adaptations by pioneers such as Langendorff and Starling to modern advancements by researchers like Morgan and Neely. We discuss the various applications of the model in pharmacological testing, disease modeling, and educational settings, emphasizing its crucial role in understanding cardiac function and disease mechanisms. Recent technological enhancements, including high-resolution imaging, integration with bioengineering, and advanced genomic and proteomic analyses, have significantly broadened the capabilities of these models. Looking forward, we explore potential future developments such as the integration of precision medicine, stem cell research, and artificial intelligence, which promise to revolutionize the use of isolated heart perfusion models. This review highlights the model's crucial role in bridging experimental research and clinical applications.

摘要

离体心脏灌注模型是心血管研究中的一项基础工具，自19世纪末问世以来已取得了显著发展。本文综述追溯了离体心脏模型的发展历程，从兰根多夫和斯塔林等先驱者的早期改良，到摩根和尼利等研究人员的现代进展。我们讨论了该模型在药理学测试、疾病建模和教育领域的各种应用，强调了其在理解心脏功能和疾病机制方面的关键作用。包括高分辨率成像、与生物工程整合以及先进的基因组和蛋白质组分析在内的最新技术改进，显著拓宽了这些模型的能力。展望未来，我们探索了诸如精准医学、干细胞研究和人工智能整合等潜在的未来发展方向，这些有望彻底改变离体心脏灌注模型的应用。本文综述突出了该模型在连接实验研究和临床应用方面的关键作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/11c2/11289247/7ecb2cb7a20d/AMS-AD-9-188270-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/11c2/11289247/84b8c8772ddf/AMS-AD-9-188270-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/11c2/11289247/19a9f37babd9/AMS-AD-9-188270-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/11c2/11289247/166654d6b7e8/AMS-AD-9-188270-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/11c2/11289247/7f93099f6aed/AMS-AD-9-188270-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/11c2/11289247/abce452fdb91/AMS-AD-9-188270-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/11c2/11289247/b9177e1c4e0e/AMS-AD-9-188270-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/11c2/11289247/4e63e21124f1/AMS-AD-9-188270-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/11c2/11289247/df8d92d5c647/AMS-AD-9-188270-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/11c2/11289247/7ecb2cb7a20d/AMS-AD-9-188270-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/11c2/11289247/84b8c8772ddf/AMS-AD-9-188270-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/11c2/11289247/19a9f37babd9/AMS-AD-9-188270-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/11c2/11289247/166654d6b7e8/AMS-AD-9-188270-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/11c2/11289247/7f93099f6aed/AMS-AD-9-188270-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/11c2/11289247/abce452fdb91/AMS-AD-9-188270-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/11c2/11289247/b9177e1c4e0e/AMS-AD-9-188270-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/11c2/11289247/4e63e21124f1/AMS-AD-9-188270-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/11c2/11289247/df8d92d5c647/AMS-AD-9-188270-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/11c2/11289247/7ecb2cb7a20d/AMS-AD-9-188270-g009.jpg

相似文献

1
History of the development of isolated heart perfusion experimental model and its pioneering role in understanding heart physiology.离体心脏灌注实验模型的发展历程及其在理解心脏生理学方面的开创性作用。
Arch Med Sci Atheroscler Dis. 2024 May 29;9:e109-e121. doi: 10.5114/amsad/188270. eCollection 2024.
2
Retrograde heart perfusion: the Langendorff technique of isolated heart perfusion.逆行心脏灌注：离体心脏灌注的 Langendorff 技术。
J Mol Cell Cardiol. 2011 Jun;50(6):940-50. doi: 10.1016/j.yjmcc.2011.02.018. Epub 2011 Mar 6.
3
The continuing evolution of the Langendorff and ejecting murine heart: new advances in cardiac phenotyping.Langendorff 心脏和射血小鼠心脏的持续进化：心脏表型分析的新进展。
Am J Physiol Heart Circ Physiol. 2012 Jul 15;303(2):H156-67. doi: 10.1152/ajpheart.00333.2012. Epub 2012 May 25.
4
Isolated heart perfusion according to Langendorff---still viable in the new millennium.根据朗格多夫法进行的离体心脏灌注——在新千年仍可行。
J Pharmacol Toxicol Methods. 2007 Mar-Apr;55(2):113-26. doi: 10.1016/j.vascn.2006.05.006. Epub 2006 May 26.
5
Isolated Perfused Hearts for Cardiovascular Research: An Old Dog with New Tricks.用于心血管研究的离体灌流心脏：老狗新把戏。
J Cardiovasc Transl Res. 2024 Oct;17(5):1207-1217. doi: 10.1007/s12265-024-10517-7. Epub 2024 May 8.
6
Isolated heart models: cardiovascular system studies and technological advances.离体心脏模型：心血管系统研究与技术进展
Med Biol Eng Comput. 2015 Jul;53(7):669-78. doi: 10.1007/s11517-015-1270-2. Epub 2015 Mar 15.
7
Advancements in Heart Failure Management: A Comprehensive Narrative Review of Emerging Therapies.心力衰竭管理的进展：新兴疗法的全面叙述性综述
Cureus. 2023 Oct 4;15(10):e46486. doi: 10.7759/cureus.46486. eCollection 2023 Oct.
8
Characterization and Validation of Radiotracer Kinetics Using the Langendorff Isolated Perfused Heart.采用 Langendorff 离体心脏模型对示踪剂动力学特性进行鉴定和验证。
Methods Mol Biol. 2024;2729:251-267. doi: 10.1007/978-1-0716-3499-8_15.
9
Isolated heart models for studying cardiac electrophysiology: a historical perspective and recent advances.用于研究心脏电生理学的离体心脏模型：历史回顾与最新进展
J Basic Clin Physiol Pharmacol. 2017 May 1;28(3):191-200. doi: 10.1515/jbcpp-2016-0110.
10
Whole-heart modeling: applications to cardiac electrophysiology and electromechanics.全心模型：在心脏电生理学和机电学中的应用。
Circ Res. 2011 Jan 7;108(1):113-28. doi: 10.1161/CIRCRESAHA.110.223610.

本文引用的文献

1
Data-Independent Acquisition Proteomics and N-Terminomics Methods Reveal Alterations in Mitochondrial Function and Metabolism in Ischemic-Reperfused Hearts.数据非依赖采集蛋白质组学和 N 端组学方法揭示缺血再灌注心脏中线粒体功能和代谢的改变。
J Proteome Res. 2024 Feb 2;23(2):844-856. doi: 10.1021/acs.jproteome.3c00754. Epub 2024 Jan 24.
2
Gene therapy during heart perfusion: a new frontier in cardiac regenerative medicine?心脏灌注期间的基因治疗：心脏再生医学的新前沿？
Front Cardiovasc Med. 2023 Oct 16;10:1264449. doi: 10.3389/fcvm.2023.1264449. eCollection 2023.
3
A tomographic microscopy-compatible Langendorff system for the dynamic structural characterization of the cardiac cycle.
一种用于心动周期动态结构表征的断层扫描显微镜兼容的Langendorff系统。
Front Cardiovasc Med. 2022 Dec 22;9:1023483. doi: 10.3389/fcvm.2022.1023483. eCollection 2022.
4
The Coadministration of Levosimendan and Exenatide Offers a Significant Cardioprotective Effect to Isolated Rat Hearts against Ischemia/Reperfusion Injury.左西孟旦与艾塞那肽联合应用对离体大鼠心脏缺血/再灌注损伤具有显著的心脏保护作用。
J Cardiovasc Dev Dis. 2022 Aug 12;9(8):263. doi: 10.3390/jcdd9080263.
5
Cardiac efficiency and Starling's Law of the Heart.心脏效率和 Starling 心脏定律。
J Physiol. 2022 Oct;600(19):4265-4285. doi: 10.1113/JP283632. Epub 2022 Sep 10.
6
Modification of the Langendorff system of the isolated beating heart for experimental radiotherapy at a synchrotron: 4000 Gy in a heart beat.用于同步加速器实验放射治疗的离体跳动心脏 Langendorff 系统的改进：在一次心跳中达到 4000Gy。
J Synchrotron Radiat. 2022 Jul 1;29(Pt 4):1027-1032. doi: 10.1107/S1600577522004489. Epub 2022 May 18.
7
High resolution optical mapping of cardiac electrophysiology in pre-clinical models.心脏电生理学的高分辨率光学标测在临床前模型中的应用。
Sci Data. 2022 Mar 31;9(1):135. doi: 10.1038/s41597-022-01253-1.
8
[Unfairly Forgotten: Carl Ludwig: The Founder of Modern Physiology].[被不公平地遗忘：卡尔·路德维希：现代生理学的奠基人]
Dtsch Med Wochenschr. 2021 Dec;146(24-25):1599-1604. doi: 10.1055/a-1338-3898. Epub 2021 Dec 8.
9
One hundred years from Otto Loewi experiment, a dream that revolutionized our view of neurotransmission.自奥托·勒维实验百年以来，这一梦想彻底改变了我们对神经传递的看法。
Pflugers Arch. 2021 Jun;473(6):977-981. doi: 10.1007/s00424-021-02580-9. Epub 2021 May 27.
10
An isolated retrograde-perfused newborn mouse heart preparation.一种分离的逆行灌注新生小鼠心脏标本。
MethodsX. 2020 Sep 8;7:101058. doi: 10.1016/j.mex.2020.101058. eCollection 2020.