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2-卤代苯甲腈与烯基硼酸的Suzuki 偶联反应产物经串联环化反应合成异喹啉酮。

Synthesis of Isoquinolones by Sequential Suzuki Coupling of 2-Halobenzonitriles with Vinyl Boronate Followed by Cyclization.

机构信息

Department of Molecular, Cellular & Developmental Biology, Yale University, New Haven, Connecticut 06511, United States.

Department of Pharmacology, Yale University, New Haven, Connecticut 06511, United States.

出版信息

J Org Chem. 2021 Jun 18;86(12):8479-8488. doi: 10.1021/acs.joc.1c00472. Epub 2021 May 28.

DOI:10.1021/acs.joc.1c00472
PMID:34047555
Abstract

A novel, facile, and expeditious two-step synthesis of 3,4-unsubstituted isoquinolin-1(2)-ones from a Suzuki cross-coupling between 2-halobenzonitriles and commercially available vinyl boronates followed by platinum-catalyzed nitrile hydrolysis and cyclization is described.

摘要

本文描述了一种新颖、简便、快速的两步法合成 3,4-取代异喹啉-1(2)-酮的方法，该方法通过 2-卤代苯甲腈与商业可得的乙烯基硼酸酯的铃木交叉偶联反应，然后进行铂催化的腈水解和环化反应。

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