Hien Phan Thi, Thoi Vu Huu, Ha Nguyen Thu, Kalach Nicolas
Vietnam National Children's Hospital, Dong Da district, Hanoi city, Vietnam. Correspondence to: Dr Phan Thi Hien, Vietnam National Children's Hospital, 18/879 La Thanh road, Dong Da district, Hanoi city, Vietnam.
Bach Mai General Hospital, Phuong Mai, Dong Da district, Hanoi city, Vietnam.
Indian Pediatr. 2021 Dec 15;58(12):1119-1123. Epub 2021 May 28.
To compare effectiveness, safety and tolerance of two colon cleansing regimens using polyethylene glycol 4000 (PEG) in children.
Prospective, randomized, open clinical trial carried out in 129 children, 3 to 18 years old undergoing colonoscopy. Patients were randomized into two groups, 64 children received PEG with electrolyte (50 mL/kg) and oral bisacodyl (PEG+B group) or 65 other children received PEG with electrolyte (70 mL/kg) and glycerol enema (PEG+G group).
Both regimens showed a good colon cleansing effectiveness with the percentage of successful cleansing being 93.8% for PEG+B regimen and 89.1% for PEG+G regimen (P=0.51). There was no statistically significant difference between the pre-regimen and post-regimen laboratory values. The rates of nausea (65.6% vs 31.3%; P<0.001) and bloating (50% vs 17.2%; P<0.001) of PEG+G group were significantly higher than that of PEG+B group.
Both regimens had good efficacy and safety for colon cleansing in children. The tolerance of PEG+B regimen was better.
比较两种使用聚乙二醇4000（PEG）的儿童结肠清洁方案的有效性、安全性和耐受性。
对129例3至18岁接受结肠镜检查的儿童进行前瞻性、随机、开放临床试验。患者被随机分为两组，64例儿童接受含电解质的PEG（50 mL/kg）和口服比沙可啶（PEG+B组），另外65例儿童接受含电解质的PEG（70 mL/kg）和甘油灌肠（PEG+G组）。
两种方案均显示出良好的结肠清洁效果，PEG+B方案的清洁成功率为93.8%，PEG+G方案为89.1%（P=0.51）。方案实施前和实施后的实验室检查值之间无统计学显著差异。PEG+G组的恶心发生率（65.6%对31.3%；P<0.001）和腹胀发生率（50%对17.2%；P<0.001）显著高于PEG+B组。
两种方案对儿童结肠清洁均具有良好的疗效和安全性。PEG+B方案的耐受性更好。
