小鼠脓毒症严重程度评分
Scoring Sepsis Severity in Mice.
机构信息
Department of Surgery, Western University, London, ON, Canada.
出版信息
Methods Mol Biol. 2021;2321:155-159. doi: 10.1007/978-1-0716-1488-4_13.
PMID:34048014
Abstract
A reliable scoring system that predicts the development of sepsis, septic shock, and death enables comparison of disease severity and treatment outcomes in animal models of sepsis. Mice are used in the majority of preclinical sepsis studies. We describe a murine sepsis score that evaluates seven clinical variables in an experimental mouse model of polymicrobial sepsis.
摘要
一个可靠的评分系统可以预测脓毒症、感染性休克和死亡的发展，从而能够比较脓毒症动物模型中疾病的严重程度和治疗结果。在大多数临床前脓毒症研究中使用小鼠。我们描述了一种小鼠脓毒症评分系统，用于评估多微生物脓毒症实验小鼠模型中的七个临床变量。
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