钯催化的烯丙酰胺碳钯化反应/与活性次甲基化合物的烯丙基化反应
Palladium-Catalyzed Allenamide Carbopalladation/Allylation with Active Methine Compounds.
作者信息
Zhu Xiaoyi, Li Ruibo, Yao Hequan, Lin Aijun
机构信息
State Key Laboratory of Natural Medicines, Jiangsu Key Laboratory of Bioactive Natural Product Research, Department of Medicinal Chemistry, China Pharmaceutical University, Nanjing 210009, P. R. China.
出版信息
Org Lett. 2021 Jun 18;23(12):4630-4634. doi: 10.1021/acs.orglett.1c01369. Epub 2021 May 28.
A palladium-catalyzed allenamide carbopalladation/allylation with active methine compounds has been developed. Various indoles and isoquinolinones bearing a quaternary carbon center were achieved with good efficiency, a broad substrate scope and good functional group tolerance. This reaction underwent cascade oxidative addition, carbopalladation, and allylic alkylation, and two new C-C bonds were formed in one pot.
已开发出一种钯催化的丙二烯酰胺与活性次甲基化合物的碳钯化/烯丙基化反应。高效地实现了各种带有季碳中心的吲哚和异喹啉酮，底物范围广且官能团耐受性良好。该反应经历串联氧化加成、碳钯化和烯丙基烷基化，在一锅反应中形成了两个新的C-C键。
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