State Key Laboratory of Fine Chemicals, School of Pharmaceutical Science and Technology, Faculty of Chemical, Environmental and Biological Science and Technology, Dalian University of Technology, Dalian 116024, P. R. China.
J Org Chem. 2012 Mar 16;77(6):2942-6. doi: 10.1021/jo2024812. Epub 2012 Feb 29.
With the direct use of allylic alcohols as allylating agents, the Friedel-Crafts-type allylic alkylation of nitrogen-containing aromatic compounds catalyzed by a [Mo(3)S(4)Pd(η(3)-allyl)] cluster is achieved. With a 3 mol % catalyst loading in acetonitrile at reflux or 60 °C, a variety of N,N-dialkylanilines and indoles reacted smoothly with allylic alcohols to afford the Friedel-Crafts-type allylation products in good to excellent yields with high levels of regioselectivity.
采用烯丙醇作为直接烯丙基化试剂，通过[Mo(3)S(4)Pd(η(3)-allyl)]簇催化实现了含氮芳环化合物的Friedel-Crafts 型烯丙基烷基化反应。在乙腈中，以 3 mol %的催化剂用量在回流或 60°C 下，各种 N,N-二烷基苯胺和吲哚与烯丙醇反应，以良好至优异的收率得到高区域选择性的 Friedel-Crafts 型烯丙基化产物。
