Key Laboratory of Marine Drugs of Ministry of Education, Shandong Provincial Key Laboratory of Glycoscience and Glycotechnology, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China.
Key Laboratory of Marine Drugs of Ministry of Education, Shandong Provincial Key Laboratory of Glycoscience and Glycotechnology, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China; Qingdao Marine Biomedical Research Institute, Qingdao 266071, China.
Int J Biol Macromol. 2021 Jul 31;183:1649-1659. doi: 10.1016/j.ijbiomac.2021.05.135. Epub 2021 May 25.
Alginate and its derivatives are widely used as food additives and dietary fibers. Previous studies indicated that alginate, polyguluronate (PG) and polymannuronate acid (PM) could be fermented by human gut microbiota. However, how different compositions of the microbiota may affect the fermentation outcomes of these polysaccharides remains unknown. Here we show that Bacteroides-dominated microbiota (Bacteroides enterotype) is more proficient at degrading and utilizing PG and PM as compared to Prevotella-dominated (Prevotella enterotype) and Escherichia-dominated microbiota (Escherichia enterotype). Enterotype dictates the fermentation outcomes of the three fibers and the amount of short-chain fatty acids (SCFAs) that are produced. Fermentation of alginate and PM by Bacteroides-dominated microbiota produced the highest amount of total SCFAs and butyrate. Our study demonstrates an enterotype-specific effect of microbiota on the fermentation of alginate and its derivatives and highlights that personalized nutrition using dietary fibers should be tailored according to individual's composition of the gut microbiome.
藻酸盐及其衍生物被广泛用作食品添加剂和膳食纤维。先前的研究表明，藻酸盐、聚古罗糖醛酸（PG）和聚甘露糖醛酸（PM）可被人类肠道微生物群发酵。然而，不同组成的微生物群如何影响这些多糖的发酵结果尚不清楚。在这里，我们表明，与拟杆菌主导型（拟杆菌型）和大肠杆菌主导型（大肠杆菌型）微生物群相比，厚壁菌门主导型（厚壁菌型）微生物群更擅长降解和利用 PG 和 PM。肠型决定了三种纤维的发酵结果以及产生的短链脂肪酸（SCFA）的量。厚壁菌门主导的微生物群发酵藻酸盐和 PM 产生的总 SCFA 和丁酸盐最多。我们的研究表明，微生物群对藻酸盐及其衍生物发酵具有特定的肠型效应，并强调应根据个体肠道微生物组的组成来定制个性化的膳食纤维营养。
