Center of Infectious Diseases and State Key Laboratory of Biotherapy, West China Hospital, West China Medical School, Sichuan University, Chengdu 610041, China; Sichuan University Library, Sichuan University, Chengdu 610041, China.
Public Health Clinical Center of Chengdu, Chengdu 610041, China.
Drug Discov Today. 2021 Sep;26(9):2190-2197. doi: 10.1016/j.drudis.2021.05.014. Epub 2021 May 26.
The Clp protease is an AAA protease that executes abnormally folded or malfunctioning proteins, and has an important role in producing virulence factors, forming biofilms or persisters and developing methicillin-resistant Staphylococcus aureus (MRSA). Recent studies showed that Clp protease controls virulence via agr signaling and degrades antitoxins of the toxin-antitoxin system to modulate the formation of persisters and biofilms. In this review, we focus on recent developments concerning the virulence and persistence regulatory pathways and resistance-related mechanism of Clp protease in S. aureus, with an overview of the Clp modulators developed to treat MRSA infection.
Clp 蛋白酶是一种 AAA 蛋白酶，可作用于异常折叠或功能失调的蛋白质，在产生毒力因子、形成生物膜或持续存在以及导致耐甲氧西林金黄色葡萄球菌 (MRSA) 方面具有重要作用。最近的研究表明，Clp 蛋白酶通过 Agr 信号控制毒力，并降解毒素-抗毒素系统的解毒素来调节持续存在和生物膜的形成。在这篇综述中，我们重点关注 Clp 蛋白酶在金黄色葡萄球菌中的毒力和持续存在调控途径以及与耐药性相关的机制的最新研究进展，并概述了为治疗 MRSA 感染而开发的 Clp 调节剂。
