Yu Bo, Sun Mengmeng, Wang Zhihong, Zhu Bing, Xue Jingquan, Yang Wenjiang, Gao Xinyan, Zhi Mujun, Cao Jiazhen, Zhao Jinying, Zhao Xuewei, Liu Wu, Wang Fuchun, Li Tie
Chinese Medicine Science and Technology Exchange Center, Beijing, P. R. China.
Changchun University of Chinese Medicine, Changchun, P. R. China.
Am J Chin Med. 2021;49(5):1151-1164. doi: 10.1142/S0192415X21500555. Epub 2021 May 27.
One of the most important aspects of clinical acupuncture practice, like diabetic gastroparesis, is the selection of suitable acupoints. Furthermore, it is critical to examine the therapeutic impact differences between distal and local acupoints, as well as the prescription of their combination. In this study, diabetic gastroparesis rats were treated by needling Zhongwan (CV12) and Zusanli (ST36), and then used Single Photon Emission Computed Tomography-CT (SPECT-CT) technology to assess the effects of promoting gastric motility. In addition, morphological observation, immunohistochemical examination, and biomarker assays, such as determination of growth factor 1, motilin, and ghrelin contents in serum samples, were performed to better understand the impact of certain various acupuncture treatments. All of the therapies improved the symptoms of diabetic gastroparesis rats, according to the findings. Stimulating these acupoints, on the other hand, can have a different therapeutic effect. In addition, needling local and distal acupoints together can have an antagonistic or synergistic impact on specific physiological and biochemical indexes such as gastric motility, ghrelin, gastrin, and growth factor 1, among others. Our findings demonstrated the benefits of acupoints and acupuncture in the management of diabetic gastroparesis, as well as a new insight into acupuncture therapeutics.
临床针灸实践（如糖尿病胃轻瘫）最重要的方面之一是合适穴位的选择。此外，研究远端穴位和局部穴位的治疗效果差异以及它们的联合处方至关重要。在本研究中，对糖尿病胃轻瘫大鼠针刺中脘（CV12）和足三里（ST36）进行治疗，然后使用单光子发射计算机断层扫描-CT（SPECT-CT）技术评估促进胃动力的效果。此外，还进行了形态学观察、免疫组化检查以及生物标志物检测，如测定血清样本中生长因子1、胃动素和胃饥饿素的含量，以更好地了解不同针刺治疗的影响。结果显示，所有治疗均改善了糖尿病胃轻瘫大鼠的症状。然而，刺激这些穴位会产生不同的治疗效果。此外，同时针刺局部和远端穴位对胃动力、胃饥饿素、胃泌素和生长因子1等特定生理生化指标可能产生拮抗或协同作用。我们的研究结果证明了穴位和针灸在糖尿病胃轻瘫管理中的益处，也为针灸治疗学提供了新的见解。
