Division of Pulmonology, Allergy and Critical Care Medicine, Department of Internal Medicine, Yongin Severance Hospital, Yonsei University College of Medicine, 363 Dongbaekjukjeon-daero, Giheung-Gu, Yongin-si, Gyeonggi-do, 16995, Republic of Korea.
Center for Digital Health, Yongin Severance Hospital, Yonsei University College of Medicine, Yongin, Gyeonggi-do, Republic of Korea.
BMC Pulm Med. 2021 May 28;21(1):180. doi: 10.1186/s12890-021-01547-x.
Although depression is a common comorbidity of chronic obstructive pulmonary disease (COPD), the role of sex remains unexplored. We evaluated sex differences of risk factors of depressive symptoms in adults with COPD.
This was a population-based cross-sectional study using data from the 2014 and 2016 Korea National Health and Nutrition Examination Survey. Spirometry was used to identify patients with COPD, defined as a FEV/FVC ratio < 0.7. Presence of depressive symptoms was defined as a total score ≥ 5 on the Patient Health Questionnaire-9.
17.8% of participants expressed depressive symptoms. Relative regression analysis revealed that female sex (RR 2.38; 95% CI 1.55-3.66; p < 0.001), living alone (RR 1.46; 95% CI 1.08-1.97; p = 0.013), current smoker (RR 1.70; 95% CI 1.15-2.52; p = 0.008), underweight (RR 1.58 95% CI 1.00-2.49; p = 0.049), and GOLD Stage III/IV (RR 1.92; 95% CI 1.19-3.09; p = 0.007) were the risk factors for depressive symptoms. Low income, living alone, multiple chronic disorders, and low BMI were risk factors of depressive symptoms in male, whereas low educational attainment, urban living, and current smoking were risk factors in female.
Female sex is a main risk factor of depressive symptoms in adults with COPD. As risk factors of depressive symptoms in COPD patients vary according to their sex, different approaches are needed to manage depression in males and females with COPD.
虽然抑郁是慢性阻塞性肺疾病（COPD）的常见合并症，但性别在其中的作用仍未得到充分探索。本研究旨在评估 COPD 患者中抑郁症状的危险因素在性别之间的差异。
这是一项基于人群的横断面研究，使用了 2014 年和 2016 年韩国国家健康和营养检查调查的数据。采用肺量测定法来识别 COPD 患者，定义为 FEV/FVC 比值<0.7。抑郁症状的存在定义为患者健康问卷-9 的总分≥5。
17.8%的参与者表现出抑郁症状。相对回归分析显示，女性（RR 2.38；95%CI 1.55-3.66；p<0.001）、独居（RR 1.46；95%CI 1.08-1.97；p=0.013）、当前吸烟者（RR 1.70；95%CI 1.15-2.52；p=0.008）、体重过轻（RR 1.58；95%CI 1.00-2.49；p=0.049）和 GOLD 分期 III/IV（RR 1.92；95%CI 1.19-3.09；p=0.007）是抑郁症状的危险因素。在男性中，低收入、独居、多种慢性疾病和低 BMI 是抑郁症状的危险因素，而在女性中，低教育程度、城市居住和当前吸烟是危险因素。
女性是 COPD 患者抑郁症状的主要危险因素。由于 COPD 患者的抑郁症状的危险因素因性别而异，因此需要针对男性和女性 COPD 患者采取不同的方法来管理抑郁。
