慢性阻塞性肺疾病患者肺功能损害与焦虑和抑郁风险之间的关联——一项系统综述
Association between impairment of lung function and risk of anxiety and depression in patients with chronic obstructive pulmonary disease-a systematic review.
作者信息
Karlsen Johanne Hermann, Jørgensen Kirstine Hermann, Weinreich Ulla Møller
机构信息
Department of Respiratory Diseases, Aalborg University Hospital, Hobrovej 18-22, 9000, AalborgC , Denmark.
Faculty of Medicine, Aalborg University, Frederik Bajers Vej 7K, 9220, Aalborg, Denmark.
出版信息
Syst Rev. 2024 Dec 4;13(1):300. doi: 10.1186/s13643-024-02720-z.
BACKGROUND
This systematic review aims to examine the association between impairment of lung function and risk of anxiety and depression, respectively, in patients with chronic obstructive pulmonary disease (COPD).
METHODS
Literature search were performed 29/01-2024 using Embase and PubMed. Publications reporting association between forced expiratory volume in one second in percentage of expected value (FEV1(%)) and either anxiety or depression or both in patients with COPD were included. The studies were quality assessed using the Newcastle Ottawa Scale. The studies were analysed by assessing whether they showed significant results or not, and if they showed a negative or positive association between lung function and risk anxiety or depression and a pooled analysis was conducted.
RESULTS
Thirty-seven studies were included in the review, 15 reported anxiety and 31 reported depression, with 9 reporting both outcomes. Most were observational studies. Study population sizes ranged from 40 to 2147 patients. Three studies found a significant negative association between anxiety and FEV1(%), while five studies found a positive non-significant association between anxiety and FEV1(%). Fifteen studies found a significant negative association between FEV1(%) and depression. Especially the studies with larger study population sizes showed significant results. The pooled analysis supported this, as the depression studies showed a significant association between depression and FEV1(%), while the anxiety studies showed part non-significant, part significant associations between anxiety and FEV1(%).
CONCLUSION
This systematic review did not support an association between anxiety and impairment of pulmonary function as only 3/15 studies showed significant negative associations, and some studies showed positive associations. This review indicated an association between depression and impairment pulmonary function in patients with COPD, as most studies with a larger study population size showed a significant negative association. Sytematic review registration. PROSPERO 2024 CRD42024506065 Available from: https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42024506065.
背景
本系统评价旨在分别研究慢性阻塞性肺疾病（COPD）患者肺功能损害与焦虑和抑郁风险之间的关联。
方法
于2024年1月29日使用Embase和PubMed进行文献检索。纳入报告COPD患者一秒用力呼气容积占预计值百分比（FEV1(%)）与焦虑或抑郁或两者之间关联的出版物。采用纽卡斯尔渥太华量表对研究进行质量评估。通过评估研究是否显示出显著结果，以及它们是否显示出肺功能与焦虑或抑郁风险之间的负相关或正相关来分析研究，并进行汇总分析。
结果
该评价纳入了37项研究，15项报告了焦虑，31项报告了抑郁，9项报告了这两种结果。大多数是观察性研究。研究人群规模从40至2147名患者不等。三项研究发现焦虑与FEV1(%)之间存在显著负相关，而五项研究发现焦虑与FEV1(%)之间存在正相关但不显著。15项研究发现FEV1(%)与抑郁之间存在显著负相关。特别是研究人群规模较大的研究显示出显著结果。汇总分析支持了这一点，因为抑郁研究显示抑郁与FEV1(%)之间存在显著关联，而焦虑研究显示焦虑与FEV1(%)之间部分不显著、部分显著相关。
结论
本系统评价不支持焦虑与肺功能损害之间存在关联，因为只有3/15的研究显示出显著负相关，且一些研究显示出正相关。该评价表明COPD患者抑郁与肺功能损害之间存在关联，因为大多数研究人群规模较大的研究显示出显著负相关。系统评价注册。PROSPERO 2024 CRD42024506065 可从以下网址获取：https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42024506065 。
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