Koerner F, Merz E, Wagner A, Gloor B
Universitäts-Augenklinik, Bern.
Klin Monbl Augenheilkd. 1988 May;192(5):465-7. doi: 10.1055/s-2008-1050153.
Preretinal dispersion of stimulated RPE cells has been suggested as a possible cause of the development of proliferative vitreoretinopathy (PVR). Retinal detachment (RD) and retinal breaks are associated with an exposure of corresponding areas of retinal pigment epithelium (RPE) which has been mechanically stimulated by coagulation. In a prospective, controlled study of 141 patients between 20 and 75 years of age, PVR grades were determined before and RD surgery and within six months following it PVR grades were correlated with the extent of RD, size of breaks, and area of coagulation. The severity of the PVR correlated significantly with both the extent of RD as well as the total number of coagulation exposures. There was a tendency toward higher grades of PVR with larger retinal breaks. The results are compatible with the hypothesis that at least certain variations of PVR are caused by preretinal dispersion of stimulated RPE cells.
受刺激的视网膜色素上皮（RPE）细胞的视网膜前分散被认为是增殖性玻璃体视网膜病变（PVR）发展的一个可能原因。视网膜脱离（RD）和视网膜裂孔与视网膜色素上皮（RPE）相应区域的暴露有关，这些区域已受到凝固的机械刺激。在一项对141名年龄在20至75岁之间的患者进行的前瞻性对照研究中，在RD手术前和手术后六个月内确定PVR分级，并将PVR分级与RD程度、裂孔大小和凝固面积相关联。PVR的严重程度与RD程度以及凝固暴露的总数均显著相关。视网膜裂孔越大，PVR分级越高的趋势越明显。这些结果与以下假设相符，即至少某些PVR的变化是由受刺激的RPE细胞的视网膜前分散引起的。
