Wei Xuejiao, Zhu Xiaoyu, Jiang Lili, Long Mengtuan, Du Yujun
The First Hospital of Jilin University, Changchun, Jilin, China.
Nephrology (Carlton). 2021 Sep;26(9):708-714. doi: 10.1111/nep.13906. Epub 2021 Jun 29.
With the continuous improvement in living standards, lifestyle changes and ageing of the population, the prevalence of chronic kidney disease (CKD) has increased significantly, and its prevention and treatment have become important public health issues worldwide. Renal fibrosis is the main pathological basis of CKD progression to end-stage renal disease. Preventing the progression of renal fibrosis has always been the focus of clinical and scientific research. Ulinastatin is a serine protease inhibitor that is found in human blood and urine and inhibits the inflammatory response, regulates immunity and improves the microcirculation. It is widely used in patients with sepsis and septic shock in clinical practice. Recent studies have shown that ulinastatin can also play an important anti-fibrotic and organ protective role and can provide a new therapeutic hope for CKD patients. This review mainly introduced the research progress of UTI in inflammation, oxidative stress, apoptosis, acute kidney injury and renal fibrosis. By investigating the role of ulinastatin in CKD, we can determine the possible mechanisms for its renal protection and improvement of renal fibrosis, so as to provide new ideas for the treatment of CKD.
随着生活水平的不断提高、生活方式的改变以及人口老龄化，慢性肾脏病（CKD）的患病率显著上升，其防治已成为全球重要的公共卫生问题。肾纤维化是CKD进展至终末期肾病的主要病理基础。预防肾纤维化的进展一直是临床和科研的重点。乌司他丁是一种丝氨酸蛋白酶抑制剂，存在于人体血液和尿液中，可抑制炎症反应、调节免疫并改善微循环。在临床实践中，它广泛应用于脓毒症和脓毒性休克患者。近期研究表明，乌司他丁还可发挥重要的抗纤维化和器官保护作用，为CKD患者提供新的治疗希望。本综述主要介绍了乌司他丁在炎症、氧化应激、细胞凋亡、急性肾损伤和肾纤维化方面的研究进展。通过探究乌司他丁在CKD中的作用，我们可以确定其肾脏保护和改善肾纤维化的可能机制，从而为CKD的治疗提供新思路。
