脂肪切除术会影响地松鼠白色脂肪组织脂蛋白脂肪酶活性和血浆甘油三酯水平。

Lipectomy influences white adipose tissue lipoprotein lipase activity and plasma triglyceride levels in ground squirrels.

作者信息

Forger N G, Dark J, Stern J S, Wade G N, Zucker I

机构信息

Department of Psychology, University of California, Berkeley 94720.

出版信息

Metabolism. 1988 Aug;37(8):782-6. doi: 10.1016/0026-0495(88)90015-7.

DOI:10.1016/0026-0495(88)90015-7

PMID:3405095

Abstract

Golden-mantled ground squirrels undergo marked fattening and fat depletion during the prehibernatory and hibernatory phases, respectively, of their annual body weight cycle. Fat regulation was studied by surgical removal (lipectomy) of most of the inguinal-subcutaneous, retroperitoneal, and parametrial fat depots from female squirrels during the weight-gain phase of the annual cycle. Seven weeks after surgery, body weights of lipectomized (Lipx) and Sham-Lipx squirrels were equivalent, although white adipose tissue was not completely recovered in Lipx animals. Lipoprotein lipase (LPL) activity was markedly elevated in subcutaneous adipose tissue of Lipx squirrels, but not in other depots. Plasma triglyceride (TG) levels also were higher in Lipx squirrels 7 weeks after surgery. Changes in LPL activity and plasma TG may contribute to body mass and lipid restoration following lipectomy.

摘要

金背地松鼠在其年度体重周期的冬眠前期和冬眠期分别经历显著的脂肪积累和脂肪消耗。在年度周期的体重增加阶段，通过手术切除（脂肪切除术）雌性松鼠大部分腹股沟皮下、腹膜后和子宫旁脂肪库来研究脂肪调节。手术后七周，脂肪切除（Lipx）松鼠和假手术松鼠的体重相当，尽管Lipx动物的白色脂肪组织没有完全恢复。脂蛋白脂肪酶（LPL）活性在Lipx松鼠的皮下脂肪组织中显著升高，但在其他脂肪库中没有。手术后七周，Lipx松鼠的血浆甘油三酯（TG）水平也更高。LPL活性和血浆TG的变化可能有助于脂肪切除术后体重和脂质的恢复。