干扰素敏感或耐药乳腺癌细胞中的2',5'寡腺苷酸合成酶水平。
2', 5' oligo (A) synthetase levels in interferon-sensitive or resistant breast cancer cells.
作者信息
Kortsaris A
机构信息
Theagenion Memorial Cancer Institute, Greece.
出版信息
Microbiologica. 1988 Apr;11(2):111-7.
PMID:3405096
Abstract
The levels of 2', 5' oligo (A) synthetase increase 15-fold when T47D cells are treated with human interferon or with interferon inducers. The results also show that interferon-treated T47D cells contain high levels of 2', 5' oligo (A) synthetase which upon incubation with ATP produces adenine oligonucleotides which are predominantly trimers. In contrast, MCF-7 and BT20 cells whether treated with interferon or not exhibit low 2', 5' oligo (A) synthetase activity.
摘要
当用人类干扰素或干扰素诱导剂处理T47D细胞时，2'，5'-寡聚腺苷酸合成酶的水平会增加15倍。结果还表明，经干扰素处理的T47D细胞含有高水平的2'，5'-寡聚腺苷酸合成酶，该酶与ATP孵育时会产生主要为三聚体的腺嘌呤寡核苷酸。相比之下，MCF-7和BT20细胞无论是否用干扰素处理，其2'，5'-寡聚腺苷酸合成酶活性都较低。
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