Department of Genetics and Molecular Biology, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional (CINVESTAV), Mexico City, Mexico; Department of Neuroscience, Functional Pharmacology, Uppsala University, Uppsala, Sweden.
Exp Gerontol. 2021 Aug;151:111425. doi: 10.1016/j.exger.2021.111425. Epub 2021 May 26.
Whales are marine creatures known for their enormous size and that live in all the oceans on earth. One of the oldest known organisms is bowhead whales, which can survive up to 200 years, and similarly, other species of whales have shown a remarkable long lifespan. In addition to this, whales are highly resistant to cancer, a disease that is strongly related to aging and the accumulation of damage over time. These two characteristics make whales an interesting model to study and that can provide us with a track both to delay aging and to avoid pathologies associated with it, such as cancer. In the present work, we try to analyze different aspects of whales such as metabolism, hematological and biochemical characteristics, and properties of their genome and transcriptome in order to elucidate possible molecular mechanisms that evolution has provided to these aquatic mammals.
鲸鱼是一种海洋生物，以其巨大的体型而闻名，生活在地球上的所有海洋中。已知最古老的生物之一是弓头鲸，它可以存活长达 200 年，类似地，其他鲸鱼物种也表现出了惊人的长寿命。除此之外，鲸鱼对癌症具有很强的抵抗力，癌症与衰老和随着时间的推移积累的损伤密切相关。这两个特征使鲸鱼成为一个有趣的研究模型，可以为我们提供一条延缓衰老和避免与衰老相关的病理的途径，如癌症。在本工作中，我们试图分析鲸鱼的不同方面，如新陈代谢、血液学和生化特征，以及它们的基因组和转录组的特性，以阐明进化为这些水生哺乳动物提供的可能的分子机制。
