Nuclear Research Center Negev (NRCN), P.O. Box 9001, 8419001, Beer-Sheva, Israel.
The Shraga Segal Department of Microbiology, Immunology and Genetics, Faculty of Health Sciences, Center for Multidisciplinary Research on Aging, Ben-Gurion University of the Negev, 8410501, Beer Sheva, Israel.
Biogerontology. 2024 Oct;25(5):891-898. doi: 10.1007/s10522-024-10129-3. Epub 2024 Aug 20.
Many biological mechanisms of aging well converge with radiation's biological effects. We used scientific insights from the field of aging to establish a novel hypoxic-hypercapnic environment (HHE) concept for radioprotection. According to this concept, HHE which possesses an anti-aging and longevity-promoting potential, should also act as a radiomitigator and radioprotector. As such, it might contribute greatly to the safety and wellbeing of individuals exposed to high levels of radiation, whether in planned events (e.g. astronauts) or in unplanned events (e.g. first responders in nuclear accidents).
许多与衰老相关的生物学机制与辐射的生物学效应相吻合。我们利用衰老领域的科学见解，为辐射防护建立了一种新的低氧-高碳酸环境（HHE）概念。根据这一概念，具有抗衰老和促进长寿潜力的低氧-高碳酸环境也应该作为一种辐射缓解剂和辐射防护剂。因此，它可能会极大地促进暴露在高水平辐射下的个体的安全和健康，无论是在计划事件（例如宇航员）中还是在非计划事件（例如核事故中的第一批救援人员）中。
