Division of School of Health Science, Department of Pathobiological Science and Technology, Faculty of Medicine, Tottori University, 86 Nishicho, Yonago, Japan.
Department of Cardiovascular Medicine, and Endocrinology and Metabolism, Faculty of Medicine, Tottori University, 36-1 Nishicho, Yonago, Japan.
Heart Fail Clin. 2021 Jul;17(3):369-376. doi: 10.1016/j.hfc.2021.02.004.
It is generally considered that obstructive sleep apnea is a potential cause of heart failure (HF), and insomnia and central sleep apnea are results of HF. However, the number of reports describing the bidirectional relationship between sleep disorder and HF has increased. Sleep disorder may contribute to left ventricular diastolic dysfunction via left atrial overload, left ventricular remodeling, pulmonary hypertension, and atrial fibrillation, which lead to HF with preserved left ventricular ejection fraction. Overnight rostral fluid shift and lung congestion may lead to airflow obstruction in the upper pharynx and stimulate pulmonary irritant receptors, which induce hyperventilation and sleep disorder.
一般认为阻塞性睡眠呼吸暂停是心力衰竭(HF)的潜在病因,而失眠和中枢性睡眠呼吸暂停则是 HF 的结果。然而,描述睡眠障碍与 HF 之间双向关系的报告数量有所增加。睡眠障碍可通过左心房负荷过重、左心室重构、肺动脉高压和心房颤动导致左心室射血分数保留型心力衰竭,从而导致左心室舒张功能障碍。夜间头侧液体转移和肺充血可能导致上咽部气流阻塞,并刺激肺激惹受体,从而引起过度通气和睡眠障碍。
Heart Fail Clin. 2021-7
Can J Cardiol. 2016-2-13
Eur Respir J. 2010-3
Am J Respir Crit Care Med. 2012-12-13
J Am Coll Cardiol. 2019-12-10
JACC Heart Fail. 2017-9-6
Sensors (Basel). 2023-2-16
Nan Fang Yi Ke Da Xue Xue Bao. 2021-8-31