Department of Psychosocial Medicine, National Center for Child Health and Development, Tokyo, Japan; Department of Child Neurology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences and Okayama University Hospital, Okayama, Japan.
Department of Child Neurology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences and Okayama University Hospital, Okayama, Japan.
Brain Dev. 2021 Oct;43(9):904-911. doi: 10.1016/j.braindev.2021.05.004. Epub 2021 May 26.
Physiological gamma and ripple activities may be linked to neurocognitive functions. This study investigated the relationship between development and non-epileptic, probably physiological, fast (40-200 Hz) oscillations (FOs) including gamma (40 - 80 Hz) and ripple (80 - 200 Hz) oscillations in scalp EEG in children with neurodevelopmental disorders.
Participants were 124 children with autism spectrum disorder (ASD) and/or attention deficit/hyperactivity disorder (ADHD). Gamma and ripple oscillations were explored from 60-second-long sleep EEG data in each subject using a semi-automatic detection tool supplemented with visual confirmation and time-frequency analysis.
Gamma and ripple oscillations were detected in 25 (20.2%) and 22 (17.7%) children, respectively. The observation of one or more occurrence(s) of ripple oscillations, but not gamma oscillations, was significantly related to lower age at EEG recording (odds ratio, OR: 0.727 [95% confidence interval, CI: 0.568-0.929]), higher intelligence/developmental quotient (OR: 1.041, 95% CI: 1.002-1.082), and lack of a diagnosis with ADHD (OR: 0.191, 95% CI: 0.039 - 0.937) according to a binominal logistic regression analysis that included diagnosis with ASD, sex, history of perinatal complications, history of febrile seizures, and use of a sedative agent for the EEG recording as the other non-significant parameters. Diagnostic group was not related to frequency or power of spectral peaks of FOs.
The production of non-epileptic scalp ripples was confirmed to be associated with brain development and function/dysfunction in childhood. Further investigation is necessary to interpret all of the information on higher brain functions that may be embedded in scalp FOs.
生理γ和涟漪活动可能与神经认知功能有关。本研究调查了神经发育障碍儿童头皮 EEG 中包括γ（40-80 Hz）和涟漪（80-200 Hz）在内的非癫痫、可能是生理性的快（40-200 Hz）振荡（FOs）的发展与非癫痫、可能是生理性的快（40-200 Hz）振荡（FOs）之间的关系。
参与者为 124 名自闭症谱系障碍（ASD）和/或注意力缺陷/多动障碍（ADHD）儿童。使用半自动检测工具，辅以视觉确认和时频分析，从每位受试者 60 秒长的睡眠 EEG 数据中探索γ和涟漪振荡。
分别在 25 名（20.2%）和 22 名（17.7%）儿童中检测到γ和涟漪振荡。观察到一个或多个涟漪振荡的发生，而不是γ振荡，与 EEG 记录时的年龄较小（比值比，OR：0.727 [95%置信区间，CI：0.568-0.929]）、智力/发育商较高（OR：1.041，95%CI：1.002-1.082）和缺乏 ADHD 诊断（OR：0.191，95%CI：0.039-0.937）显著相关根据包含 ASD 诊断、性别、围产期并发症史、热性惊厥史和 EEG 记录中镇静剂使用的二项逻辑回归分析，这些参数不显著。诊断组与 FOs 频谱峰的频率或功率无关。
证实非癫痫性头皮涟漪的产生与儿童期大脑发育和功能/功能障碍有关。需要进一步研究来解释可能嵌入头皮 FOs 的所有关于高级大脑功能的信息。
