与颞叶癫痫工作记忆缺陷相关的神经振荡变化。
Alterations in neural oscillations related to working memory deficit in temporal lobe epilepsy.
机构信息
General Medicine Department, Tianjin Medical University General Hospital, Tianjin 300052, China; Tianjin Neurological Institute, Tianjin 300052, China.
Department of Neurology, Tianjin Medical University General Hospital, Tianjin 300052, China.
出版信息
Epilepsy Behav. 2021 Aug;121(Pt A):108063. doi: 10.1016/j.yebeh.2021.108063. Epub 2021 May 27.
OBJECTIVE
Working memory (WM) is critical for higher level cognition, but the underlying neural mechanisms are not fully understood. Impaired WM affects routine daily activities and is observed in patients with temporal lobe epilepsy (TLE). This study investigated neural oscillations associated with different WM phases, to determine the specific neural activity linked with the phases of WM impairment.
METHODS
Patients with TLE (n = 52) and healthy volunteers (n = 35) completed a WM task, during which 34-channel electroencephalogram signals were recorded. Characteristic neural oscillation patterns during each WM phase were compared between the 2 groups.
RESULTS
Patients with TLE showed decreased theta power during the encoding phase of WM, which was associated with reduced accuracy in the WM task. Altered theta power in the frontal region of the brain during the encoding phase was associated with a longer reaction time.
CONCLUSIONS
Alterations in theta oscillation are related to WM impairment in patients with TLE and may serve as an early marker for evaluating WM deficits.
SIGNIFICANCE
This study provides an early marker for evaluating WM deficits in TLE.
目的
工作记忆（WM）对高级认知至关重要，但其潜在的神经机制尚不完全清楚。WM 受损会影响日常常规活动，并且在颞叶癫痫（TLE）患者中也可观察到。本研究调查了与不同 WM 阶段相关的神经振荡，以确定与 WM 损伤阶段相关的特定神经活动。
方法
TLE 患者（n=52）和健康志愿者（n=35）完成了 WM 任务，在此期间记录了 34 通道脑电图信号。比较了两组在每个 WM 阶段的特征性神经振荡模式。
结果
TLE 患者在 WM 的编码阶段表现出θ功率降低，这与 WM 任务的准确性降低有关。在编码阶段大脑额叶区域的θ功率改变与反应时间延长有关。
结论
θ振荡的改变与 TLE 患者的 WM 损伤有关，可作为评估 WM 缺陷的早期标志物。
意义
本研究为评估 TLE 中的 WM 缺陷提供了一个早期标志物。
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