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Monocytes and macrophages in severe COVID-19 - friend, foe or both?

作者信息

Dress Regine J, Ginhoux Florent

机构信息

Institute of Systems Immunology (ISI), Center for Molecular Neurobiology (ZMNH), University Medical Center Hamburg-Eppendorf, Hamburg, 20251, Germany.

Singapore Immunology Network (SIgN), Agency for Science, Technology and Research (A*STAR), Singapore, 138648, Singapore.

出版信息

Immunol Cell Biol. 2021 Jul;99(6):561-564. doi: 10.1111/imcb.12464. Epub 2021 May 30.

DOI:10.1111/imcb.12464
PMID:34053124
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8242688/
Abstract
摘要

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Pathogenic T-cells and inflammatory monocytes incite inflammatory storms in severe COVID-19 patients.致病性T细胞和炎性单核细胞在重症COVID-19患者中引发炎症风暴。
Natl Sci Rev. 2020 Jun;7(6):998-1002. doi: 10.1093/nsr/nwaa041. Epub 2020 Mar 13.
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Longitudinal profiling of respiratory and systemic immune responses reveals myeloid cell-driven lung inflammation in severe COVID-19.严重 COVID-19 患者肺部炎症由髓系细胞驱动的呼吸道和全身免疫反应纵向分析。
Immunity. 2021 Apr 13;54(4):797-814.e6. doi: 10.1016/j.immuni.2021.03.005. Epub 2021 Mar 11.
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Inflammatory profiles across the spectrum of disease reveal a distinct role for GM-CSF in severe COVID-19.疾病谱中的炎症特征表明 GM-CSF 在重症 COVID-19 中具有显著作用。
Sci Immunol. 2021 Mar 10;6(57). doi: 10.1126/sciimmunol.abg9873.
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Major alterations in the mononuclear phagocyte landscape associated with COVID-19 severity.与 COVID-19 严重程度相关的单核吞噬细胞景观的主要改变。
Proc Natl Acad Sci U S A. 2021 Feb 9;118(6). doi: 10.1073/pnas.2018587118.
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Early Phases of COVID-19 Are Characterized by a Reduction in Lymphocyte Populations and the Presence of Atypical Monocytes.COVID-19 的早期阶段表现为淋巴细胞群减少和存在非典型单核细胞。
Front Immunol. 2020 Dec 9;11:560330. doi: 10.3389/fimmu.2020.560330. eCollection 2020.
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Mayo Clin Proc. 2020 Nov;95(11):2382-2394. doi: 10.1016/j.mayocp.2020.08.038. Epub 2020 Sep 3.
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Cell. 2020 Sep 17;182(6):1401-1418.e18. doi: 10.1016/j.cell.2020.08.002. Epub 2020 Aug 5.
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Severe COVID-19 Is Marked by a Dysregulated Myeloid Cell Compartment.严重的 COVID-19 以髓系细胞失调为特征。
Cell. 2020 Sep 17;182(6):1419-1440.e23. doi: 10.1016/j.cell.2020.08.001. Epub 2020 Aug 5.
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Longitudinal analyses reveal immunological misfiring in severe COVID-19.纵向分析揭示了重症 COVID-19 中的免疫失调。
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Impaired type I interferon activity and inflammatory responses in severe COVID-19 patients.严重 COVID-19 患者的 I 型干扰素活性和炎症反应受损。
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